S100A11, S100 calcium binding protein A11, 6282

N. diseases: 103; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. 29375710 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.050 Biomarker phenotype BEFREE We investigated the effect of silencing S100A11 on TGF-β1-induced epithelial-mesenchymal transition (EMT), cell migration and invasion. 29569474 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.050 Biomarker phenotype BEFREE This study aimed to identify the function of S100A11 associated with cell proliferation and invasion in gastric cancer. 30662594 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 Biomarker phenotype BEFREE Four of these (AHNAK, septin-9, eIF4E, and S100A11) are shown to be essential for pseudopod protrusion and tumor cell migration and invasion. 20388789 2010
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.050 Biomarker phenotype BEFREE Four of these (AHNAK, septin-9, eIF4E, and S100A11) are shown to be essential for pseudopod protrusion and tumor cell migration and invasion. 20388789 2010
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.050 Biomarker phenotype BEFREE In human bladder cancer, overexpression of S100A4, S100A8 or S100A11 are associated with stage progression, invasion, metastasis and poor survival. 17523080 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.050 AlteredExpression phenotype LHGDN S100A11 gene expression was clearly up-regulated in specimens from patients with lymph node metastases relative to those from patients without lymph node metastases. 15138568 2004
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.040 Biomarker phenotype BEFREE S100A11 (calgizzarin), a member of the S100 family, is associated with oncogenesis, inflammation and myocardial damage. 30684913 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.040 Biomarker phenotype BEFREE Our results suggested that S100A11 could activate the PI3K/Akt/mTOR signaling pathway in HSCC tumorigenesis. 31312359 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.040 Biomarker phenotype BEFREE S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. 29375710 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.040 Biomarker phenotype BEFREE Collectively, our results demonstrated that EIF3C overexpression is a potential target of angiogenesis for treatment with exosome inhibitor or S100A11 reduction to suppress HCC angiogenesis and tumorigenesis. 29568350 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 AlteredExpression group BEFREE Among the three subtypes, S100A11 levels were significantly higher in adenocarcinomas with KRAS mutations and strong proliferating activity. 26544866 2015
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 Biomarker group BEFREE Further immunohistochemistry staining was positive for S100A11 only in non-small cell lung cancer (NSCLC) (ADC, SCC, large cell carcinomas, et al.), but not SCLC. 21861103 2012
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 AlteredExpression group BEFREE Real-time reverse transcription-PCR analysis of human colorectal cancer cell lines and adenocarcinomas revealed that altered expression levels were also observed for six of the genes Igfbp5, Lcn2, Ly6d, N4wbp4 (PMEPA1), S100c, and Sox4. 15665292 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 AlteredExpression group BEFREE In benign prostatic hyperplasia (n=30) and benign tissue adjacent to adenocarcinoma (n=54), S100A11 expression was significantly higher in basal cells compared with in luminal cells (P <0.001). 15668896 2004
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma
0.030 Biomarker disease BEFREE Our results showed that S100A11 was obviously increased in ICC tumor tissues. 30182496 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.030 Biomarker disease BEFREE We explored the role of S100A11 in the proliferation and apoptosis of pancreatic cancer cell line PANC-1 and the potential mechanisms involving the TGF-β<sub>1</sub>/SMAD4/p21 pathway. 29922945 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.030 Biomarker disease BEFREE Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers. 30850029 2019
Secondary malignant neoplasm of lymph node
0.030 Biomarker disease BEFREE The nomograms comprising LNM and S100A11 achieved better predictive accuracy compared with TNM staging system for OS and RFS prediction. 30182496 2019
Secondary malignant neoplasm of lymph node
0.030 AlteredExpression disease BEFREE S100A11 expression was positively correlated with the FIGO stage and lymph node metastasis of CSCC patients (P < 0.05). 31695426 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.030 AlteredExpression disease BEFREE S100A11 overexpression has been reported in a number of cancers including papillary thyroid carcinoma, colon, pancreatic, and breast cancer. 30662594 2018
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.030 Biomarker disease BEFREE This study aimed to identify the function of S100A11 associated with cell proliferation and invasion in gastric cancer. 30662594 2018
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.030 AlteredExpression disease BEFREE S100A11 overexpression has been reported in a number of cancers including papillary thyroid carcinoma, colon, pancreatic, and breast cancer. 30662594 2018
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma
0.030 Biomarker disease BEFREE S100A11 promotes TGF-β1-induced epithelial-mesenchymal transition through SMAD2/3 signaling pathway in intrahepatic cholangiocarcinoma. 29569474 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.030 Biomarker disease BEFREE Immunohistochemical analyses of S100A11 and phosphorylated (p)-AKT serine/threonine kinase (AKT) were performed in 30 resected specimens from patients with pancreatic cancer. 29375710 2018