S100A11, S100 calcium binding protein A11, 6282

N. diseases: 103; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.030 AlteredExpression disease BEFREE S100A11 overexpression has been reported in a number of cancers including papillary thyroid carcinoma, colon, pancreatic, and breast cancer. 30662594 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.030 Biomarker disease BEFREE This study aimed to identify the function of S100A11 associated with cell proliferation and invasion in gastric cancer. 30662594 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 Biomarker disease BEFREE Collectively, our results demonstrated that EIF3C overexpression is a potential target of angiogenesis for treatment with exosome inhibitor or S100A11 reduction to suppress HCC angiogenesis and tumorigenesis. 29568350 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.030 Biomarker disease BEFREE S100A11 was significantly increased in synovial fluid (p < 0.0001) but not in serum (p = 0.158) from patients with RA compared to patients with OA when adjusted for age and sex. 28446208 2017
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.030 GeneticVariation disease BEFREE We detected upregulated S100A2, S100A6, S100A10, and S100A11 expression and downregulated S100P and S100B expression in GC. 25266115 2015
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.030 AlteredExpression disease BEFREE S100A6, S100A11 and its putative interaction partner annexin A1 showed the highest overexpression in PTC compared to normal thyroid.S100A13 was also elevated in PTC. 25880590 2015
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma
0.030 AlteredExpression disease BEFREE The S100 family members on chromosome 1q21 were extensively upregulated in ICC, and S100A11 had the greatest degree of upregulation in ICC. 25712376 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.030 GeneticVariation disease BEFREE We detected upregulated S100A2, S100A6, S100A10, and S100A11 expression and downregulated S100P and S100B expression in GC. 25266115 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.030 AlteredExpression disease BEFREE Using MDA-MB-231 as a model breast cancer cell line, we provide evidence that PFN1 overexpression is associated with alterations in the expression of proteins that have been functionally linked to cell proliferation (FKPB1A, HDGF, MIF, PRDX1, TXNRD1, LGALS1, STMN1, LASP1, S100A11, S100A6), survival (HSPE1, HSPB1, HSPD1, HSPA5 and PPIA, YWHAZ, CFL1, NME1) and motility (CFL1, CORO1B, PFN2, PLS3, FLNA, FLNB, NME2, ARHGDIB). 25454514 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.030 Biomarker disease BEFREE Bioinformatics analysis showed increased mRNA expression of Damage-Associated Molecular Patterns (DAMPs): HMGA, HMGB, HMGN, SRY, LEF1, HMGB1, MMPs, and HMG/RAGE-interacting molecules (spondins and S100A4, S100A10, and S100A11) in human OA-affected cartilage as compared with normal cartilage. 24905701 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.030 AlteredExpression disease BEFREE Using MDA-MB-231 as a model breast cancer cell line, we provide evidence that PFN1 overexpression is associated with alterations in the expression of proteins that have been functionally linked to cell proliferation (FKPB1A, HDGF, MIF, PRDX1, TXNRD1, LGALS1, STMN1, LASP1, S100A11, S100A6), survival (HSPE1, HSPB1, HSPD1, HSPA5 and PPIA, YWHAZ, CFL1, NME1) and motility (CFL1, CORO1B, PFN2, PLS3, FLNA, FLNB, NME2, ARHGDIB). 25454514 2014
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma
0.030 AlteredExpression disease BEFREE We found that the S100A11 gene expression is frequently up-regulated in PTC, anaplastic thyroid carcinoma, but not in follicular thyroid carcinoma. 23928665 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 Biomarker disease BEFREE Furthermore, the overexpression of S100A11 can promote HCC cell invasiveness, whereas siRNA against S100A11 can suppress the invasiveness of HCC cells stably transfected with EGFRvIII. 24376686 2013
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.030 AlteredExpression disease BEFREE Chondrocyte RAGE expression and S100A11 release are stimulated by IL-1beta in vitro and increase in OA cartilage in situ. 18523305 2008
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.030 Biomarker disease LHGDN Chondrocyte RAGE expression and S100A11 release are stimulated by IL-1beta in vitro and increase in OA cartilage in situ. 18523305 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.030 AlteredExpression disease LHGDN S100A6 and S100A11 can discriminate significantly between the two primary tumor entities, CRC and HCC, whereas S100A6 allows the discrimination of metastases and HCC. 19048101 2008
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.030 Biomarker disease BEFREE S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. 15138568 2004
Secondary malignant neoplasm of lymph node
0.030 AlteredExpression disease BEFREE S100A11 gene expression was clearly up-regulated in specimens from patients with lymph node metastases relative to those from patients without lymph node metastases. 15138568 2004
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.030 Biomarker disease BEFREE S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. 15138568 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.030 AlteredExpression disease BEFREE Two of these genes, L19 and MLN70, were previously reported to be overexpressed in breast cancer. 10752678 2000
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.030 AlteredExpression disease BEFREE Two of these genes, L19 and MLN70, were previously reported to be overexpressed in breast cancer. 10752678 2000
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease
0.020 Biomarker group BEFREE Furthermore, we present a protocol for assessment of chromosomal aberrations after depletion of S100A11 that illustrate the apparent involvement of S100A11 in genome integrity. 30710290 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.020 Biomarker disease BEFREE We also demonstrated the S100A11 on tumour growth in GBM using an orthotopic tumour xenografting. 31430050 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 Biomarker group BEFREE We also demonstrated the S100A11 on tumour growth in GBM using an orthotopic tumour xenografting. 31430050 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.020 Biomarker disease BEFREE We explored the role of S100A11 in the proliferation and apoptosis of pancreatic cancer cell line PANC-1 and the potential mechanisms involving the TGF-β<sub>1</sub>/SMAD4/p21 pathway. 29922945 2019