|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes.
|
31093843 |
2019 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TA(48/49), K(151), and AA(48/49) in the Nef gene might be associated with the different stages of HIV infection, and there may be a link between the Nef secondary structure and the progression of HIV-1 infection.
|
19263804 |
2008 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The maintenance of intact NEF open reading frames with conserved functional domains and a low degree of genetic variability following vertical transmission supports the notion that NEF plays an important role in HIV-1 infection and replication in mothers and their perinatally infected infants.
|
12824703 |
2004 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review briefly explores the role of the nef gene during HIV-1 infection and highlights the expectation that RNA interference might serve as a new sequence-specific therapeutic arsenal in AIDS prevention, and possibly treatment, in the years ahead.
|
12837615 |
2003 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the HIV-1 nef gene in five intravenous drug users with long-term nonprogressive HIV-1 infection in Italy.
|
10630962 |
2000 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A 36-bp deletion close to the 5' end of NEF that impaired Nef function was found in a long-term nonprogressor with human immunodeficiency virus type 1 (HIV-1) infection.
|
10608759 |
2000 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that sequence variations in Nef are associated with different stages of HIV-1 infection and suggest a link between nef gene function and the immune status of the infected individual.
|
10364298 |
1999 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-2 infection than in HIV-1 infection.
|
9722912 |
1998 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, one individual with nonprogressive HIV-1 infection yielded an unusually high frequency of disrupted nef open reading frames and Nef proteins defective for CD4 downregulation.
|
8892896 |
1996 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other reports have suggested that the nef gene may not be the only gene involved, but attenuations in other accessory genes (vif, vpr, vpu), which play an important role in the viral life cycle, may be similarly important in chronic HIV-1 infection in LTNPs.
|
8806556 |
1996 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we conclude that the genotypic and phenotypic features of nef are not likely to account for the nonprogression of HIV-1 infection in the 10 cases studied, unless the function of the nef gene in vivo is not accurately reflected by the in vitro assays we used.
|
7494338 |
1995 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of the nef gene in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood.
|
1501274 |
1992 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since F14.11 is able to identify nef protein in the cytoplasm of lymphocytes from HIV-infected seronegative subjects it may prove useful in monitoring the expression of nef during the silent HIV-1 infection.
|
2064828 |
1991 |