|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that -13T is a genetic background for AA amyloidosis in both Japanese and Caucasians and the difference in prevalence of AA amyloidosis in the two ethnic groups may be due, at least in part, to a difference in the frequency of the -13T SAA1 allele.
|
12762135 |
2003 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SAA1 gene polymorphisms and the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis.
|
17039310 |
2006 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the SAA1 -13T allele, rather than SAA1 exon 3 haplotypes, is primarily associated with AA amyloidosis risk.
|
11407685 |
2001 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, the SAA1 polymorphism was confirmed as a susceptibility factor for AA amyloidosis irrespective of the type of the disease.
|
29364741 |
2018 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis.
|
17968686 |
2007 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, the mean C-reactive protein (CRP) level during 2 years prior to the diagnosis of AA-amyloidosis was significantly higher in the patients with larger numbers of the gamma allele at the SAA1 locus (Spearman's correlation coefficient: 0.34, P<0.05).
|
10543406 |
1999 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
His mother was also a carrier of the SAA1.3 allele, which is not only a univariate predictor of survival but also a risk factor for the association of AA amyloidosis with rheumatoid arthritis in Japanese patients, and the SAA1-13T allele in the 13T/C polymorphism on the 5'-flanking region of the SAA1 gene.
|
24593212 |
2014 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We treated 14 RA patients who had serum amyloid A protein (SAA) 1.3 allele, with biopsy-confirmed AA amyloidosis with etanercept and investigated the efficacy of etanercept treatment, focusing on renal function retrospectively.
|
20440529 |
2010 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Development of AA amyloidosis is rare in FMF patients without amyloidogenic single nucleotide polymorphisms (SNPs) (713T allele) of the SAA1 gene.
|
19339884 |
2009 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous reports have indicated that the -13T/C single nucleotide polymorphism (SNP) at the 5'-flanking region of SAA1 appears to be a better marker of AA-amyloidosis than the exon-3 based haplotype, i.e., SAA1.1 or SAA1.3, in both Japanese and American Caucasian populations.
|
16076608 |
2005 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Of the four human SAA genotypes, SAA1 is most commonly associated with AA amyloidosis.
|
24440699 |
2014 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Another report revealed a strong association between SAA1 -13T/C and secondary amyloidosis in the rheumatoid arthritis patient group.
|
16874691 |
2006 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients with FMF or a rheumatic disease and the SAA1 α/α genotype had a relative risk of 4.86 and 2.53, respectively, for developing an AA amyloidosis.
|
25376380 |
2015 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results of the analysis of real data indicated that a significant association between haplotypes in the SAA1 gene and AA-amyloidosis phenotype was observed in patients with rheumatoid arthritis, thereby suggesting the validity of the application of PENHAPLO for case-control data.
|
16980401 |
2006 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The contributions of ageing, inflammatory activity, SAA1 exon 3 polymorphism as well as gender to the pathogenesis of AA amyloidosis in 144 cases were also studied by multiple regression analysis.
|
21627560 |
2011 |
|
Reactive systemic amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we report that there was a significant difference in the observed numbers of SAA1 alleles between rheumatoid arthritis patients with AA-amyloidosis and the control population (chi 2(2) = 11.59, p = 0.003) with a higher frequency of gamma-allele in the AA-amyloid group (0.70 vs. 0.37).
|
7655463 |
1995 |
|
Amyloid nephropathy
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of the risk factors, and phenotype-genotype correlation of familial Mediterranean fever (FMF) gene (MEFV) and serum amyloid A1 (SAA1) gene polymorphisms in renal amyloidosis.
|
16118480 |
2005 |
|
Amyloid nephropathy
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Overall, these data, which provide new insights into the pathophysiology of FMF, demonstrate that susceptibility to renal amyloidosis in this Mendelian disorder is influenced by at least two MEFV-independent factors of genetic origin-SAA1 and sex-that act independently of each other.
|
11017802 |
2000 |
|
Amyloid nephropathy
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Indeed, the SAA1 alpha homozygous genotype and the p.Met694Val homozygous genotype at the MEFV locus are two main risk factors for RA.
|
19888326 |
2009 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relative transcriptional activities of SAA1 promoters polymorphic at position -13(T/C): potential association between increased transcription and amyloidosis.
|
16076608 |
2005 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the gamma/gamma genotype and gamma alleles at the SAA1 locus were significantly higher in the amyloidosis population than in the early RA population (34.9% versus 7.8%, and 58.1% versus 33.8%, chi2 test P=0.0001).
|
10543406 |
1999 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
M694V homozygocity, male gender and the alpha/alpha genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis.
|
16283319 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest a protective effect of the SAA1 beta and gamma alleles on the development of amyloidosis and show the absence of a MICA modifying effect on amyloidosis development.
|
15018633 |
2004 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan.
|
16736418 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis for amyloidosis corrected risk revealed a 1.2 times increase in M694V/M694V, a 2.4 times increase in SAA1 alpha/alpha genotypes and a 2.5 times increase when both are together.
|
16118480 |
2005 |