|
Obesity
|
0.360 |
Biomarker
|
disease |
BEFREE |
In light of the differences in gene expression and metabolic function of visceral (V) and subcutaneous (S) adipose tissue (AT) and their resident cells, the aim of this study was to investigate the role of SIRT1 and SIRT2 in the differentiation of adipose stem cells (ASCs) isolated from SAT and VAT biopsies of nondiabetic obese and nonobese individuals.
|
31462690 |
2020 |
|
Obesity
|
0.360 |
Biomarker
|
disease |
BEFREE |
Expression of genes involved in BCAA catabolism in VAT (but not SAT) was lower in patients with obesity than in lean controls.
|
31440954 |
2020 |
|
Obesity
|
0.360 |
Biomarker
|
disease |
BEFREE |
SAT1-aKO mice developed late-onset obesity on a high-fat diet with impaired cold-induced beige adipocyte biogenesis and energy expenditure.
|
29715464 |
2018 |
|
Obesity
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our data suggest that we should look at SAT as composed of distinct depots with possibly different impact in obesity associated metabolic complications.
|
28231762 |
2017 |
|
Obesity
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined whether there are site-specific differences between visceral and subcutaneous adipose tissue (VAT and SAT, respectively) ORM gene and protein expression from individuals with a wide range of obesity and the relationship between expressed and circulating ORM levels and measures of adiposity, insulin resistance, and pro- and anti-inflammatory markers and adipokines.
|
22134720 |
2012 |
|
Obesity
|
0.360 |
Biomarker
|
disease |
CTD_human |
Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers.
|
20882379 |
2011 |
|
Obesity
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigate if the 2 single nucleotide polymorphisms rs4730153 and G-948T are associated with obesity and/or related traits and whether they influence the messenger RNA (mRNA) levels of PBEF1 (originally the abbreviation for pre-B-cell colony-enhancing factor 1) in visceral and subcutaneous adipose tissue (VAT and SAT).
|
18940394 |
2008 |
|
Depressive disorder
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
However, it is unknown whether this effect is associated with depression or with suicide and whether all or only specific isoforms expressed by SAT1, such as the primary 171 amino acid protein-encoding transcript (SSAT), or an alternative splice variant (SSATX) that is involved in SAT1 regulated unproductive splicing and transcription (RUST), are involved.
|
25959060 |
2015 |
|
Depressive disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
These results add support for a role of SAT1 in conferring a risk for suicide completion, in particular in the context of depressive disorders.
|
19851986 |
2010 |
|
Depressive disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
These results add support for a role of SAT1 in conferring a risk for suicide completion, in particular in the context of depressive disorders.
|
19851986 |
2010 |
|
Depressive disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
These findings suggest that downregulation of SAT1 expression may play a role in depression and suicidality, possibly by impeding the normal PSR program or through compensation for the increased polyamine metabolism accompanying the psychological distress associated with depressive disorders.
|
19152344 |
2009 |
|
Depressive disorder
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that downregulation of SAT1 expression may play a role in depression and suicidality, possibly by impeding the normal PSR program or through compensation for the increased polyamine metabolism accompanying the psychological distress associated with depressive disorders.
|
19152344 |
2009 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
BEFREE |
Given that the SAT-MC uses geometric shapes, is nonverbal and less culturally loaded than other social cognition measures, it may serve for measuring ToM in schizophrenia across cultures.
|
29958750 |
2018 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
To clarify the role SAT1 genetic variation plays in suicidal behavior risk, we present a whole-gene sequencing effort of SAT1 in 476 bipolar disorder subjects with a history of suicide attempt and 473 subjects with bipolar disorder but no suicide attempts.
|
27229768 |
2016 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
BEFREE |
Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in major depression and suicide.
|
25959060 |
2015 |
|
Major Depressive Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in major depression and suicide.
|
25959060 |
2015 |
|
Keratosis pilaris decalvans
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Mutations in MBTPS2 have been reported to cause a broad phenotypic spectrum of X-linked genodermatoses, including IFAP (ichthyosis follicularis; atrichia and photophobia) syndrome (OMIM 308205) with or without BRESHECK (brain anomalies, retardation of mentality and growth, ectodermal dysplasia, skeletal malformations, Hirschsprung disease, ear deformity and deafness, eye hypoplasia, cleft palate, cryptorchidism, and kidney dysplasia/hypoplasia) syndrome, keratosis follicularis spinulosa decalvans (KFSD; OMIM 308800) and an X-linked form of Olmsted syndrome.
|
24313295 |
2014 |
|
Bipolar Disorder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In our study we tested the effect of in vitro lithium treatment on SAT1 gene and protein expression in B lymphoblastoid cell lines (BLCLs) from bipolar disorder (BD) patients who committed suicide (and for which BLCLs were collected prior to their death), BD patients with high and low risk of suicide and a sample of non-psychiatric controls.
|
23768751 |
2013 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Fourth, we show that the blood levels of SAT1 (spermidine/spermine N1-acetyltransferase 1), the top biomarker identified by us, at the time of testing for this study, differentiated future as well as past hospitalizations with suicidality, in a live cohort of bipolar disorder subjects, and exhibited a similar but weaker pattern in a live cohort of psychosis (schizophrenia/schizoaffective disorder) subjects.
|
23958961 |
2013 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
In our study we tested the effect of in vitro lithium treatment on SAT1 gene and protein expression in B lymphoblastoid cell lines (BLCLs) from bipolar disorder (BD) patients who committed suicide (and for which BLCLs were collected prior to their death), BD patients with high and low risk of suicide and a sample of non-psychiatric controls.
|
23768751 |
2013 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We failed to demonstrate a significant association between the SAT-1 -1415T/C SNP and schizophrenia, but a mild association between allele C and psychopathology was found in the female group.
|
19162121 |
2009 |
|
Unipolar Depression
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
SAT1 cortical expression levels were also found to be significantly lower in an independent sample of German subjects with major depression who died by suicide in comparison with controls.
|
19152344 |
2009 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
SAT1 cortical expression levels were also found to be significantly lower in an independent sample of German subjects with major depression who died by suicide in comparison with controls.
|
19152344 |
2009 |
|
Major Depressive Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
SAT1 cortical expression levels were also found to be significantly lower in an independent sample of German subjects with major depression who died by suicide in comparison with controls.
|
19152344 |
2009 |
|
Major Depressive Disorder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
SAT1 cortical expression levels were also found to be significantly lower in an independent sample of German subjects with major depression who died by suicide in comparison with controls.
|
19152344 |
2009 |