SERPINB4, serpin family B member 4, 6318

N. diseases: 64; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023646
Disease: Lichen Planus
Lichen Planus 		0.010 AlteredExpression disease BEFREE The mean serum SCCA2 levels in patients with eruptive LP were significantly higher compared to those with localized (P < .05) and hypertrophic (P < .01) forms. 31815365 2019
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.010 Biomarker disease BEFREE Here, we report SCCA1 in relation to the immune and peritumoral adipose tissue microenvironment in early and advanced esophageal adenocarcinoma (EAC). 30825353 2019
CUI: C1275122
Disease: Familial multiple trichoepitheliomata
Familial multiple trichoepitheliomata 		0.010 AlteredExpression disease BEFREE In conclusion, poor prognosis in EAC overexpressing SCCA1 is due to reduced tumor chemosensitivity as well as intratumoral immunity impairment, likely induced by this molecule. 30825353 2019
CUI: C0015230
Disease: Exanthema
Exanthema 		0.010 AlteredExpression phenotype BEFREE Expression of SCCA2 in AD eruption was examined by immunohistochemistry. 28734739 2018
CUI: C0023891
Disease: Liver Cirrhosis, Alcoholic
Liver Cirrhosis, Alcoholic 		0.010 Biomarker disease BEFREE The aim of this study was to investigate the diagnostic sensitivity and specificity of protein induced by vitamin K absence or antagonist-II (PIVKAII), Glypican-3 (GP3), Cystatin B (CSTB), squamous cell carcinoma antigen 1 (SCCA1) and hepatocyte growth factor (HGF) as potential tumour markers for HCC in patients with alcoholic liver cirrhosis (ALC) using imaging techniques (MSCT and MRI) as reference standards. 28766361 2018
CUI: C0206721
Disease: Inverted Papilloma
Inverted Papilloma 		0.010 Biomarker disease BEFREE We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. 30376194 2018
CUI: C0740919
Disease: Allergy to grass pollen
Allergy to grass pollen 		0.010 AlteredExpression disease BEFREE Expression of SERPINB3 and SERPINB4 mRNA was measured in in vitro-cultured T<sub>H</sub>2 cells and in ex vivo CD27<sup>-</sup>CD4<sup>+</sup> cells and innate lymphoid cell (ILC) 2 from patients with grass pollen allergy by using quantitative PCR. 29106998 2018
CUI: C1881254
Disease: Inverted Squamous Cell Papilloma
Inverted Squamous Cell Papilloma 		0.010 Biomarker disease BEFREE We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. 30376194 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.010 GeneticVariation disease BEFREE Here we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival after anti-CTLA4 immunotherapy in two independent cohorts of patients with melanoma (n = 174). 27668655 2016
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.010 AlteredExpression group BEFREE Overexpression of squamous cell carcinoma antigen 1 (SCCA1) in hepatitis G2 (HepG2) and Chinese hamster ovary cells can increase hepatitis B virus (HBV) binding capacity by interacting with the preS1 domain of the HBV surface antigen. 22359459 2012
CUI: C0019159
Disease: Hepatitis A
Hepatitis A 		0.010 AlteredExpression disease BEFREE Overexpression of squamous cell carcinoma antigen 1 (SCCA1) in hepatitis G2 (HepG2) and Chinese hamster ovary cells can increase hepatitis B virus (HBV) binding capacity by interacting with the preS1 domain of the HBV surface antigen. 22359459 2012
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.010 GeneticVariation disease BEFREE To explore SCCA-1 polymorphism in patients with HCV infection as single etiologic factor and different extent of liver disease. 18657489 2009
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.010 GeneticVariation group BEFREE To explore SCCA-1 polymorphism in patients with HCV infection as single etiologic factor and different extent of liver disease. 18657489 2009
CUI: C0024620
Disease: Primary Malignant Liver Neoplasm
Primary Malignant Liver Neoplasm 		0.010 AlteredExpression disease BEFREE SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA1) is a member of the ov-serpins, a serine protease inhibitors family expressed in many cell types including normal epithelium, leukocytes, tumors of epithelial origin and primary liver cancer. 19332150 2009
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0279606
Disease: Childhood Hepatocellular Carcinoma
Childhood Hepatocellular Carcinoma 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0279607
Disease: Adult Hepatocellular Carcinoma
Adult Hepatocellular Carcinoma 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0341439
Disease: Chronic liver disease
Chronic liver disease 		0.010 Biomarker group BEFREE Furthermore, our data in this homogenous subset of patients- particularly that confirming no role for SCCA-1 - suggests that the choice of optimal biomarkers for HCC surveillance may be determined by the aetiology of underlying chronic liver disease. 18638391 2008
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0850639
Disease: premalignant lesion
premalignant lesion 		0.010 Biomarker phenotype BEFREE The objectives of this study were to prove the relationship of squamous cell carcinoma antigen 2 (SCCA2) mRNA expression in peripheral blood with non-malignant lesion, premalignant lesion, and carcinoma of the esophagus at the same assay, as well as to evaluate whether or not SCCA2 mRNA expression in peripheral blood may be a biomarker for monitoring the premalignant lesion of the disease. 19125792 2008
CUI: C0343641
Disease: Human papilloma virus infection
Human papilloma virus infection 		0.010 Biomarker disease BEFREE The SCCA2/A1 mRNA ratios were not significantly associated with types of human papillomavirus infection (P > 0.05). 17291250 2007
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 Biomarker disease BEFREE Using a construct containing the 5'-flanking region of the SCCA2 gene between -460 and +0 bp and the luciferase reporter gene, SCCA2 promoter activity was detected in SCCA2-producing SCC cell lines (LK-2, LC-1), but not in SCCA2-nonproducing lung adenocarcinoma cell lines (A549, ABC-1, and RERF-LC-MS) or normal cells (WI-38, SAEC, and NHEK-Adult). 16710347 2006
CUI: C0751688
Disease: Malignant Squamous Cell Neoplasm
Malignant Squamous Cell Neoplasm 		0.010 Biomarker disease BEFREE Squamous cell carcinoma antigens SCCA1 and SCCA2 are highly homologous serine proteinase inhibitors which have been widely utilized as serological markers for squamous cell cancers, but it has recently been demonstrated that only SCCA2 is truly specific for certain forms of lung cancer. 16710347 2006
CUI: C0021368
Disease: Inflammation
Inflammation 		0.010 AlteredExpression phenotype LHGDN Uteroglobin suppresses SCCA gene expression associated with allergic asthma. 15677460 2005
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 GeneticVariation group BEFREE A novel SCCA1 variant has been identified in one third of liver tumours. 14970861 2004