SERPINB4, serpin family B member 4, 6318

N. diseases: 64; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.030 AlteredExpression disease BEFREE HNSCC cell lines were transfected with a mammalian expression vector with SCCA1 cDNA. 16155915 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker disease BEFREE Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4), members of the ovalbumin serpin (ov-serpin)/clade B serpin family, were originally discovered as tumor-specific antigens and are used as tumor markers for various kinds of squamous cell carcinomas. 29642409 2018
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.010 GeneticVariation group BEFREE SCCA2-like serpins mediate genetic predisposition to skin tumors. 12702576 2003
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.010 GeneticVariation group LHGDN SCCA2-like serpins mediate genetic predisposition to skin tumors. 12702576 2003
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.020 Biomarker group BEFREE Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity. 30825353 2019
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.020 Biomarker disease BEFREE Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity. 30825353 2019
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.020 Biomarker disease BEFREE Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity. 30825353 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 GeneticVariation group BEFREE T357A variant has a significantly higher frequency in nonencapsulated tumors than wild type SCCA1 (p = 0.034).The SCCA1, 2 mRNA is effective for detecting HCC and could be potentially applied in HCC diagnosis. 25150316 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation disease BEFREE T357A variant has a significantly higher frequency in nonencapsulated tumors than wild type SCCA1 (p = 0.034).The SCCA1, 2 mRNA is effective for detecting HCC and could be potentially applied in HCC diagnosis. 25150316 2014
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 GeneticVariation group BEFREE A novel SCCA1 variant has been identified in one third of liver tumours. 14970861 2004
CUI: C0279606
Disease: Childhood Hepatocellular Carcinoma
Childhood Hepatocellular Carcinoma 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0279607
Disease: Adult Hepatocellular Carcinoma
Adult Hepatocellular Carcinoma 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.010 Biomarker disease BEFREE AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. 18638391 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker disease BEFREE Also, weak SCCA-2 immunoreactivity is observed in the SCC lesions, but only SCCA-1 in uterine cervical specimens with nonspecific inflammation. 21274549 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 Biomarker disease BEFREE Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. 31378660 2019
CUI: C0013595
Disease: Eczema
Eczema 		0.050 Biomarker disease BEFREE Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. 31378660 2019
CUI: C0432443
Disease: Deletion of long arm of chromosome 18
Deletion of long arm of chromosome 18 		0.010 Biomarker disease BEFREE An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA. 9887335 1999
CUI: C0809935
Disease: Chromosome 18, trisomy 18q
Chromosome 18, trisomy 18q 		0.010 Biomarker disease BEFREE An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA. 9887335 1999
CUI: C3495421
Disease: Chromosome 18q syndrome
Chromosome 18q syndrome 		0.010 Biomarker disease BEFREE An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA. 9887335 1999
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 AlteredExpression phenotype BEFREE An expression of squamous cell carcinoma antigen 2 in peripheral blood within the different stages of esophageal carcinogenesis. 19125792 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression disease LHGDN Cervical squamous cell carcinoma cell lines, CaSki cells and SKG-IIIa cells were incubated with SCCA1 or SCCA2 and MMP production was analyzed by gelatin zymography. 16211231 2005
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.040 Biomarker disease BEFREE Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy. 18497852 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 Biomarker disease BEFREE Elevated levels of the serine protease inhibitors SERPINB3 and SERPINB4 are seen in patients with atopic dermatitis and psoriasis. 25111616 2015
CUI: C0013595
Disease: Eczema
Eczema 		0.050 Biomarker disease BEFREE Elevated levels of the serine protease inhibitors SERPINB3 and SERPINB4 are seen in patients with atopic dermatitis and psoriasis. 25111616 2015