SERPINB4, serpin family B member 4, 6318

N. diseases: 64; N. variants: 0
Disease: Hepatitis B ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 Biomarker disease BEFREE Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus. 22359459 2012
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 Biomarker disease LHGDN We demonstrated that approximately 30% of the mouse liver cells expressed a high level of recombined SCCA1 protein for at least 37 d. The HBV surface antigen was found to persist in mouse liver for up to 17 d. Furthermore, HBV genome also persisted in mouse liver, as determined by polymerase chain reaction, for up to 17 d, and in mouse circulation for 7 d. These results suggest that SCAA1 might serve as an HBV receptor or co-receptor and play an important role in mediating HBV entry into hepatocytes, although its role in human HBV infection remains to be determined. 16820864 2006
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.030 Biomarker disease BEFREE Hydrophobicity of reactive site loop of SCCA1 affects its binding to hepatitis B virus. 15902720 2005