|
Carcinoma
|
0.500 |
Biomarker
|
group |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
|
Carcinoma
|
0.500 |
Biomarker
|
group |
RGD |
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.
|
12419843 |
2002 |
|
Carcinoma
|
0.500 |
Biomarker
|
group |
CTD_human |
cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.
|
12376462 |
2002 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Further investigation identified that the PPARα-SCD1 axis plays an important role in maintenance of the CSC properties of HCC sphere cells by promoting nuclear accumulation of β-Catenin.
|
31370822 |
2019 |
|
Liver carcinoma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We performed ribosomal-depleted RNA-seq profiling of HCC and para-carcinoma tissues and analyzed the expression of a hotspot circRNA derived from the 3'UTR of the stearoyl-CoA desaturase (SCD) gene, termed SCD-circRNA 2.
|
31235426 |
2019 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Together, our studies reveal novel Ras-dependent functions of Wnt signaling in remodeling the lipid metabolism of cancerous hepatocytes in zebrafish and identify the SCD inhibitor MK8245 as a candidate drug for therapeutic intervention.<b>Significance:</b> These findings identify FA desaturation as a significant downstream therapeutic target for antagonizing the combinatorial effects of Wnt and Ras signaling pathways in hepatocellular carcinoma.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/19/5548/F1.large.jpg <i></i>.
|
30065049 |
2018 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Stearoyl-CoA desaturase 1 (SCD1) is an established molecular target in many primary tumors including breast, lung, pancreatic, colon and hepatocellular carcinomas.
|
29552293 |
2018 |
|
Liver carcinoma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our integrated analysis found LC3B Y113C, BECN1 I403T, SCD1 R126S and SCD1 Y218C as highly deleterious HCC-associated mutations.
|
28085066 |
2017 |
|
Liver carcinoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
SCD was overexpressed in activated HSC and HCC cells from patients; levels of SCD messenger RNA (mRNA) correlated with HCC stage and patient survival time.
|
28143772 |
2017 |
|
Liver carcinoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, SCD1 was markedly upregulated in our established sorafenib-resistant PDTX model, and its overexpression predicts the clinical response of HCC patients to sorafenib treatment.
|
28647567 |
2017 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our findings reveal a novel role for SCD1 in the regulation of autophagy via AMPK signaling and provide mechanistic input for the clinical exploration that the combination of SCD1 inhibition with autophagy induction may be attractive for the management of HCC.
|
25528629 |
2015 |
|
Liver carcinoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Combined expression of SCD and α-fetoprotein were associated with outcomes of patients with early-stage HCC.
|
23376425 |
2013 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
CTD_human |
Suppression of the genes adenosine triphosphate citrate lyase, acetyl-CoA carboxylase, fatty acid synthase, stearoyl-CoA desaturase 1, or sterol regulatory element-binding protein 1, which are involved in lipogenesis, reduced proliferation, and survival of HCC cell lines and AKT-dependent cell proliferation.
|
21147110 |
2011 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
The defect in lipolysis in PML-deficient HBsAg-transgenic mice made the HBsAg-induced adipose-like liver tumors vulnerable to synthetic lethality from toxic saturated fat accumulation with a Scd1 inhibitor.
|
29684791 |
2018 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Lay summary: In this study, SCD1 was found to play a critical role in regulating liver tumor-initiating cells and sorafenib resistance through the regulation of ER stress-mediated differentiation.
|
28647567 |
2017 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
We assessed the functions of SCD by pharmacologic and conditional genetic manipulation in mice with hepatotoxic or cholestatic induction of liver fibrosis, orthotopic transplants of TICs, or liver tumors induced by administration of diethyl nitrosamine.
|
28143772 |
2017 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.
|
12419843 |
2002 |
|
Malignant neoplasm of liver
|
0.320 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first evidence that sorafenib disrupts lipogenesis and triggers liver cancer cell death by targeting SCD1 through the ATP-AMPK-mTOR-SREBP1 pathway.-Liu, G., Kuang, S., Cao, R., Wang, J., Peng, Q., Sun, C. Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids <i>via</i> the ATP-AMPK-mTOR- SREBP1 signaling pathway.
|
31199678 |
2019 |
|
Malignant neoplasm of liver
|
0.320 |
Biomarker
|
disease |
BEFREE |
Targeting SCD1 in combination with sorafenib may be a novel therapeutic strategy against liver cancer.
|
28647567 |
2017 |
|
Malignant neoplasm of liver
|
0.320 |
Biomarker
|
disease |
CTD_human |
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.
|
12419843 |
2002 |
|
Thyroid associated opthalmopathies
|
0.310 |
Biomarker
|
disease |
BEFREE |
We found associations of SNPs in IEGs and SCD with GD and/or GO; however, confirmation in a different population is required.
|
24780075 |
2014 |
|
Thyroid associated opthalmopathies
|
0.310 |
Biomarker
|
disease |
CTD_human |
COX-2 and SCD, markers of inflammation and adipogenesis, are related to disease activity in Graves' ophthalmopathy.
|
17614770 |
2007 |
|
Steatohepatitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data show that SCD1 is involved in nucleotide (ATP and NAD<sup>+</sup> ) metabolism and suggest that the SCD1-dependent regulation of muscle steatosis and insulin sensitivity are mediated by cooperation between AMPK- and SIRT1-regulated pathways.
|
31241768 |
2020 |
|
Fatty Liver
|
0.300 |
Biomarker
|
disease |
BEFREE |
The potential markers of fatty liver are: oleic acid, vaccenic acid, EPA, DHA, docosapentaenoic acid, and desaturase index (SCD-18 index).
|
31752380 |
2019 |
|
Fatty Liver
|
0.300 |
Biomarker
|
disease |
BEFREE |
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.
|
31226399 |
2019 |