|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Associations of DM, levels of BGP, vitamin D and VC were evaluated.
|
30759309 |
2019 |
|
Vascular calcification
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Furthermore, since warfarin inhibits the vitamin K-dependent gamma-glutamyl carboxylation of proteins, including osteocalcin and matrix Gla protein, use of warfarin may increase the risk of osteoporotic bone fracture and vascular calcification, both of which are the leading causes of morbidity that diminish the quality of life in diabetic patients.
|
30691466 |
2019 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Similarly, sera from "VC group" were more effective than sera from "no VC group" in adjuvanting the high-Pi effect of increasing osteoblastic markers, such as bone morphogenic protein 2 (BMP2), osteocalcin (OC), and runt-related transcription factor 2 (RUNX2; 39.1 ± 11.3 vs. 5.0 ± 2.6 BMP2; 12.2 ± 4.2 vs. 1.7 ± 0.3 OC; 2.9 ± 0.4 vs. 1.2 ± 0.2 RUNX2; VC vs. no VC group respectively; p < 0.05).
|
30726841 |
2019 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Further analysis by immunohistochemical staining demonstrated that the deposition was correlated with the increased expression of bone-associated proteins such as bone morphogenetic proteins-2 (BMP-2) and osteocalcin and collagen I, which suggested that inflammation induces osteogenic differentiation in vascular tissues and that osteogenic cells are the main cellular components involved in VC.
|
29761287 |
2019 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Vitamin K supplementation was associated with significant reduction in VC (-9.1% (95% CI -17.7 to -0.5); p=0.04) and VKDP (desphospho-uncarboxylated matrix Gla protein; -44.7% (95% CI -65.1 to -24.3), p<0.0001) and uncarboxylated osteocalcin; -12.0% (95% CI -16.7 to -7.2), p<0.0001) compared with control, with a non-significant improvement in VS.
|
30514729 |
2019 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Whether osteocalcin acts as a mediator or a marker of vascular calcification is currently unclear.
|
30287742 |
2018 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
There is also a relationship between lower circulating OC and ucOC and increased measures of vascular calcification and cardiovascular disease.
|
28289780 |
2017 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This systematic review and meta-analysis aimed to identify any association between OC and vascular calcification and atherosclerosis.
|
28824544 |
2017 |
|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, the expression of VC-related proteins including bone morphogenetic protein and osteocalcin were increased in the model group, whereas alpha-smooth muscle actin was decreased in the model group compared with the control group.
|
28332248 |
2017 |
|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that EPCs, through OCN expression, may directly participate in the process of VC.
|
25339701 |
2014 |
|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Since OC expression may contribute to vascular calcification, we hypothesize a putative protective role of VDRA therapy.
|
23485859 |
2013 |
|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We also observed that subjects with the CC and CT genotypes had lower levels of undercarboxylated osteocalcin (a regulator for the bone), probably vascular calcification, and lower levels of protein induced in vitamin K absence or antagonism II (PIVKA-II, a des-gamma-carboxy prothrombin) than those with TT genotypes.
|
16549638 |
2006 |