SCP2, sterol carrier protein 2, 6342

N. diseases: 50; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234649
Disease: Abnormal saccadic eye movement
Abnormal saccadic eye movement 		0.100 Biomarker disease HPO
CUI: C0239882
Disease: Head tremor
Head tremor 		0.100 Biomarker phenotype HPO
CUI: C0948896
Disease: Primary hypogonadism
Primary hypogonadism 		0.100 Biomarker disease HPO
CUI: C2364082
Disease: Sense of smell impaired
Sense of smell impaired 		0.100 Biomarker phenotype HPO
CUI: C4021243
Disease: Abnormality of thalamus morphology
Abnormality of thalamus morphology 		0.100 Biomarker disease HPO
CUI: C4025707
Disease: Abnormal motor neuron morphology
Abnormal motor neuron morphology 		0.100 Biomarker disease HPO
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases 		0.100 Biomarker group HPO
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.030 Biomarker disease BEFREE Studies in vitro have suggested that both sterol carrier protein-2/sterol carrier protein-x (<i>Scp-2/Scp-x</i>) and liver fatty acid binding protein [<i>Fabp1</i> (L-FABP)] gene products facilitate hepatic uptake and metabolism of lipotoxic dietary phytol. 28411199 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.030 Biomarker disease BEFREE In vitro studies suggest that liver fatty acid binding protein (L-FABP) and sterol carrier protein-2/sterol carrier protein-x (SCP2/SCPx) gene products facilitate uptake and metabolism and detoxification of dietary-derived phytol in mammals. 27940000 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.030 AlteredExpression disease BEFREE Primarily in female mice, hepatic cholesterol accumulation induced by SCP-2 overexpression was associated with increased levels of LDL-receptor, HDL-receptor scavenger receptor-B1 (SR-B1) (as well as PDZK1 and/or membrane-associated protein 17 kDa), SCP-2, liver fatty acid binding protein (L-FABP), and 3alpha-hydroxysteroid dehydrogenase, without alteration of other proteins involved in cholesterol uptake (caveolin), esterification (ACAT2), efflux (ATP binding cassette A-1 receptor, ABCG5/8, and apolipoprotein A1), or oxidation/transport of bile salts (cholesterol 7alpha-hydroxylase, sterol 27alpha-hydroxylase, Na(+)/taurocholate cotransporter, Oatp1a1, and Oatp1a4). 19289417 2009
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.020 Biomarker disease BEFREE Although singly ablating Fabp1 or Scp2/Scpx genes may exacerbate the impact of high fat diet (HFD) on whole body phenotype and non-alcoholic fatty liver disease (NAFLD), concomitant upregulation of the non-ablated gene, preference for ad libitum fed HFD, and sex differences complicate interpretation. 29307784 2018
CUI: C4023113
Disease: Small vessel vasculitis
Small vessel vasculitis 		0.020 Biomarker disease BEFREE In line with this, CD1d-restricted type II NKT cells that recognize type II collagen peptide have been demonstrated to act as anti-inflammatory cells in diverse inflammation-induction models in mice, whereas pro-inflammatory CD1d-restricted type II NKT cells reactive with sterol carrier protein 2 peptide have been demonstrated to be involved in the development of small vessel vasculitis in rats. 29599785 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.020 AlteredExpression disease BEFREE Based on the results, the promoting effects of EPA-PC on NAFLD may be partly associated with the suppression of cholesterol synthesis via HMGR inhibition and the enhancement of fecal cholesterol excretion through increased SCP2 transcription. 28012135 2017
CUI: C4023113
Disease: Small vessel vasculitis
Small vessel vasculitis 		0.020 Biomarker disease BEFREE Furthermore, immunization with rSCP2<sub>518-532</sub> accelerated the development of SVV in the rat model. 27863214 2017
CUI: C0856727
Disease: Cholesterol gallstones
Cholesterol gallstones 		0.020 AlteredExpression disease BEFREE Moreover, SCP2 was expressed at higher levels in hereditary cholesterol gallstone patients than that of non-hereditary cholesterol gallstone patients. 21310066 2011
CUI: C0856727
Disease: Cholesterol gallstones
Cholesterol gallstones 		0.020 Biomarker disease BEFREE The SCP2 gene was overexpressed in patients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone. 15730934 2005
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia 		0.010 AlteredExpression disease BEFREE In vivo, SCP2 overexpression and high cholesterol diet could promote tumor growth. 31519191 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.010 Biomarker disease BEFREE SCP-1 and SCP-2 also increased the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), as well as decreased the content of malondialdehyde (MDA) in the hyperglycemia mice. 30529353 2019
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.010 AlteredExpression disease BEFREE Forced expression of SCP2 promoted PA cell lines proliferation in vitro. 31519191 2019
CUI: C0158731
Disease: Congenital pectus carinatum
Congenital pectus carinatum 		0.010 Biomarker disease BEFREE Here, we evaluated the expression characteristics of miR-15a and its relationship with the expression of acetyl-CoA acyltransferase 1 (<i>ACAA1</i>), acyl-CoA oxidase 1 (<i>ACOX1</i>) and sterol carrier protein 2 (<i>SCP2</i>) by qPCR analysis in Gushi chicken breast muscle at 6, 14, 22, and 30 weeks old, where we performed transfection tests of miR-15a mimics in intramuscular preadipocytes and verified the target gene of miR-15a in chicken fibroblasts (DF1). 31434294 2019
CUI: C0220668
Disease: Congenital contractural arachnodactyly
Congenital contractural arachnodactyly 		0.010 Biomarker disease BEFREE Genes MRPS18A, CST1, and SCP2 were identified as candidate genes in the module, which was associated with clinical traits including pathological stage, histological grade, and liver function and which also affected overall survival of CCA patients. 31177590 2019
CUI: C0240765
Disease: Acquired pectus carinatum
Acquired pectus carinatum 		0.010 Biomarker disease BEFREE Here, we evaluated the expression characteristics of miR-15a and its relationship with the expression of acetyl-CoA acyltransferase 1 (<i>ACAA1</i>), acyl-CoA oxidase 1 (<i>ACOX1</i>) and sterol carrier protein 2 (<i>SCP2</i>) by qPCR analysis in Gushi chicken breast muscle at 6, 14, 22, and 30 weeks old, where we performed transfection tests of miR-15a mimics in intramuscular preadipocytes and verified the target gene of miR-15a in chicken fibroblasts (DF1). 31434294 2019
CUI: C4554344
Disease: IgE-mediated food allergy
IgE-mediated food allergy 		0.010 Biomarker disease BEFREE Over-expression of Tri tu 14 in wheat would represent a risk for patients with nsLTP-mediated FA. 30199586 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 Biomarker disease BEFREE SCP2/SCPx deficiency attenuated atherosclerosis in LS mice by >80% and significantly reduced plasma cholesterol and triglyceride levels. 29700117 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease BEFREE SCP2/SCPx deficiency attenuated atherosclerosis in LS mice by >80% and significantly reduced plasma cholesterol and triglyceride levels. 29700117 2018