|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MCP-1 production in lymph nodes from tuberculosis patients was also markedly increased.
|
9573123 |
1998 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, pleural fluid from patients with tuberculosis contained significantly (P<.001) more biologically active MIP-1alpha and MCP-1 (C-C cytokines) than did effusions from patients with congestive heart failure.
|
9780267 |
1998 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
We used specific pharmacologic inhibitors to identify the signalling molecules which lead to interleukin (IL)-8 and MCP-1 production in human monocytes in response to M. tuberculosis infection.
|
12393171 |
2002 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that persons bearing the MCP-1 genotype GG produce high concentrations of MCP-1, which inhibits production of IL-12p40 in response to M. tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis.
|
16352737 |
2005 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied the association between genetic polymorphisms of three chemokines, monocyte chemoattractant protein-1 (MCP-1), RANTES (regulated on activation, normal T cell expressed and secreted) and macrophage inflammatory protein-1alpha (MIP-1alpha), and tuberculosis (TB).
|
17625600 |
2007 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given the roles played by IFN-gamma and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené.
|
18713057 |
2008 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MCP-1 -362C was associated with resistance to TB in the case-control collection (OR 0.83, P(corr) = 0.00017) and in the affected families (OR 0.7, P(corr) = 0.004).
|
18940815 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls.
|
19942750 |
2009 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CCL2 secretion in response to M. tuberculosis was significantly greater than to BCG in the PTB and D-ETB groups.
|
20041183 |
2009 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Carriers of these susceptibility genotypes might be at increased risk of developing TB because they produce high levels of MCP-1, which enhances the induction of MMP-1 production by M. tuberculosis-sonicate antigens to higher levels than in carriers of the other two-locus MCP-1 MMP-1 genotypes studied.
|
20111728 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genomic DNA from patients with active TB (168 cases of pulmonary TB and 55 cases of extrapulmonary TB) and ethnically controls (150 cases) was genotyped for the MCP-1 -2518 A/G SNP by polymerase chain reaction fragment length polymorphism (PCR-RFLP).
|
21384169 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a Ghanaian tuberculosis (TB) case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance to TB were recently described.
|
21504590 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study found an association of the CCL2 tag SNP rs4586 C allele and pediatric TB disease in males, suggesting that gender may affect the susceptibility to TB even in children.
|
21556333 |
2011 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have therefore carried out a detailed analysis of CCL-2 genotype SNP -2518 (A/G transition) with plasma CCL-2 levels and related these levels to tuberculin skin test positivity in asymptomatic community controls with no known exposure to tuberculosis and in recently exposed household contacts of pulmonary tuberculosis patients.
|
21991356 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CCL2-2518G allele (OR 1.51, 95%CI 1.11-2.04, P = 0.008) showed significant association with susceptibility to TB.
|
22137597 |
2012 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The monocyte chemotactic protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of monocytes to M. tuberculosis infection sites, and previous studies have reported that genetic variants in MCP1 are associated with differential susceptibility to pulmonary tuberculosis (PTB).
|
22384203 |
2012 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Peripheral blood mononuclear cells obtained from 21 pulmonary tuberculosis (PTB) patients and 24 healthy controls (HCs) were cultured for 48 h with culture filtrate antigen (CFA) of Mycobacterium tuberculosis with or without vitamin D(3) at a concentration 1 × 10(-7)M. The relative mRNA expression of monocyte chemoattractant protein-1 (MCP-1, CCL2), macrophage inflammatory protein-1α (MIP-1α, CCL3), macrophage inflammatory protein-1β (MIP-1β, CCL4), and regulated upon-activation, normal T cell-expressed and secreted (RANTES, CCL5) and IFN-γ inducible protein-10 (IP-10, CXCL10) chemokines were estimated from 48 h old macrophages using real-time polymerase chain reaction (RT-PCR).
|
22800603 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that the -2518A/G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans.
|
22859936 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the relationship between -2518A/G and -362G/C polymorphisms in MCP-1 gene and the susceptibility of tuberculosis, a systematic literature search for relevant articles published up to January, 2013 was conducted in the databases of PubMed, Elsevier, Web of Science, Wanfang and CNKI.
|
23933403 |
2013 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore the role of the MCP-1 gene in the susceptibility to PTB in a North Chinese population, we evaluated the association between MCP-1 -2518A/G gene polymorphisms and the risk for tuberculosis.
|
25966175 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results revealed an association between the MCP-1 -2518A/G polymorphism and human TB susceptibility under a recessive model (GG vs GA+AA), dominant model (GG+GA vs AA), and homozygote comparison (GG vs AA) model for the entire database.
|
26125747 |
2015 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the DEGs, such as CD14 molecule (CD14) and chemokine (C-C motif) ligand 2 (CCL2), were enriched mostly in the pathways related to tuberculosis, phagosome and NF-kappa B signaling pathway.
|
26503224 |
2016 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic association meta-analysis: a new classification to assess ethnicity using the association of MCP-1 -2518 polymorphism and tuberculosis susceptibility as a model.
|
26518714 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72-0.88]).
|
26524966 |
2015 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results indicate a specific role for both p38 MAPK and IL-4 in ESAT-6-induced MCP-1 production by macrophages and suggest a pathway with significance in tuberculosis pathogenesis.
|
27154637 |
2016 |