|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic ablation of CCL2 or pharmacologic targeting of its receptor CCR2 abates mechanically-induced exacerbation of arthritis, indicating that stress-induced chemokine release by mesenchymal cells and chemo-attraction of monocytes determines preferential homing of arthritis to certain hot spots.
|
30397205 |
2018 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.
|
29145862 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Injection of recombinant CCL2 into one of the affected joints of Nfat5+/- mice increased joint destruction and macrophage infiltration, demonstrating the essential role of the NFAT5/CCL2 axis in arthritis progression in vivo.
|
28192374 |
2017 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the chemokine signaling pathway associated with CCL2 in peripheral blood (PB) and synovial tissues (ST) of RA patients based on our previous work about chemokine signaling pathway involved in the activation of CCL2 production in collagen-induced arthritis rat ST.
|
26069140 |
2015 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several inhibitors of CCL2 and its receptor CCR2 are in development and may find application for treatment of certain inflammatory conditions, including autoimmune and viral arthritides.
|
24696480 |
2014 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As chemerin enhanced expression of TLR4 and induced release of CCL2 in SFs, a role of this protein in innate immune system-associated joint inflammation is proposed.
|
22037282 |
2012 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PB, SF and ST of 14 autoantibody (AB)-positive (rheumatoid factor [RF]-IgM, RF-IgA, anti-citrullinated peptide [CCP]), 13 negative RA and 13 no-RA chronic arthritides were examined for B-cell subsets (Bm1-Bm5 and IgD-CD27 classifications), zeta-associated protein kinase-70 (ZAP70) expression on B cells and cytokine levels (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-6, IL-8 and monocyte chemotactic protein [MCP]-1).
|
21607290 |
2012 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of pro-inflammatory cytokines such as IL-8, IL-6, MIP-1β, and MCP-1 suggests that T and B cells, macrophages and neutrophils modulate joint inflammation by an immune response.
|
20012054 |
2011 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence from mouse models suggests targeting MCP-1 or complement may emerge as viable new treatment options for viral arthritides.
|
19788897 |
2009 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of individuals having G at position -2518 of the MCP-1 gene was also increased among patients with arthritis (P(c)=0.028, OR 2.99, 95%CI 1.13-8.08).
|
15611878 |
2005 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
The frequency of individuals having G at position -2518 of the MCP-1 gene was also increased among patients with arthritis (P(c)=0.028, OR 2.99, 95%CI 1.13-8.08).
|
15611878 |
2005 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histopathological assessment of joint sections demonstrated that HYPER-IL-6 increased arthritis severity and controlled intrasynovial mononuclear leukocyte recruitment through the CC-chemokine CCL2.
|
12960349 |
2003 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The demonstration of the beneficial effects of an MCP-1 antagonist in arthritis suggests that chemokine receptor antagonists could have therapeutic application in inflammatory diseases.
|
9207007 |
1997 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Synovial fluid (SF) from rheumatoid arthritis (RA), osteoarthritis, gout, and traumatic arthritis contained MCP-1.
|
8403545 |
1993 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MCP-1 levels were significantly higher (P less than 0.05) in synovial fluid from RA patients (mean 25.5 +/- 8.1 ng/ml [SE]) compared to synovial fluid from osteoarthritis (OA) patients (0.92 +/- 0.08), or from patients with other arthritides (2.9 +/- 1.5).
|
1522232 |
1992 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of cells producing MCP-1 mRNA in synovial tissues from patients with arthritis shows that this gene is expressed in vivo and suggests that MCP-1 can play a role in recruiting monocytes in joint inflammation.
|
1624809 |
1992 |