|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
CCNP was more efficient than CC in limiting the increase in inflammatory cytokine levels (such as TNF-<i>α</i>, IL-6, IL-1<i>α</i>, IL-1<i>β</i>, MCP-1, and RANTES) after MI.
|
31205590 |
2019 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Administration of WRW4 inhibitor to mice primed immature and inactive neutrophils infiltration Ly6G<sup>int</sup> and intensified the Ccl2 expression compared to MI-control in the infarcted LV post-MI.
|
31216426 |
2019 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Genetically determined higher MCP-1 levels were further associated with coronary artery disease (OR, 1.04; 95% CI, 1.00-1.08; P=0.04) and myocardial infarction (OR, 1.05; 95% CI, 1.01-1.09; P=0.02), but not with atrial fibrillation.
|
30586705 |
2019 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Many studies in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI).
|
28566450 |
2017 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the mRNA expression levels of inflammatory-related molecules such as Il6, Mcp1, Ly6g, Cd11b, matrix metallopeptidase (Mmp)9, and the protein expression levels of phosphorylated NF-κB p65, phosphorylated ERK, and phosphorylated p38 were also significantly lower in MI+SR than in MI+V.
|
29232411 |
2017 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, rs1131498" genes_norm="6402">F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286).
|
26662939 |
2016 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
We hypothesised that pulmonary venous hypertension (PVH) following MI provides a mechanical stimulus for structural remodelling of the lung via monocyte chemoattractant protein-1 (MCP-1).
|
25223582 |
2014 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In further subgroup analysis based on ethnicity, there were significant associations between MCP-1-2518A>G polymorphism and an increased risk of MI among Asian populations.
|
24053559 |
2013 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
However MCP-1 release from the human heart following MI is also suppressed, which is the exact opposite of the animal model.
|
21910857 |
2011 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects.
|
19639050 |
2009 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
RGD |
Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction.
|
18459941 |
2009 |
|
Myocardial Infarction
|
0.300 |
Therapeutic
|
disease |
RGD |
In post-MI heart failure, ARB attenuated MCP-1 expression and macrophage infiltration in the border zone, resulting in less myocardial fibrosis.
|
18753699 |
2008 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Coronary collaterals: the role of MCP-1 during the early phase of acute myocardial infarction.
|
18158188 |
2008 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The association between the -2518G/A polymorphism of the MCP-1 gene and MI was no longer significant after adjustment for other well-established risk factors.
|
18230355 |
2008 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results do not support the extent of risk associated with developing MI previously reported for the CCR2 190 and MCP-1 -2518 polymorphisms.
|
16356504 |
2006 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive analysis of common polymorphisms of CCL2 in a large community-based population and in subjects with MI found that the A(-2138)T polymorphism affected the serum MCP-1 level in a subgroup of subjects 65 years and older.
|
16799229 |
2006 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data are consistent with the hypothesis that MCP-1 is involved in the pathogenesis of human atherosclerosis and myocardial infarction.
|
16116069 |
2005 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
LHGDN |
Our data are consistent with the hypothesis that MCP-1 is involved in the pathogenesis of human atherosclerosis and myocardial infarction.
|
16116069 |
2005 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction.
|
16164699 |
2005 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction.
|
14517168 |
2003 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction.
|
14517168 |
2003 |