|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aqueous humor levels of vascular endothelial growth factor, soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and inflammatory factors (monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, and IL-8) were significantly higher in the AMD group than in the cataract group (all p < 0.05).
|
30048978 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depletion of CCL2 and CX3CR1 in Crb1rd8 mice abolished the efficacy of ZQMT, suggesting that CCL2 and/or CX3CR1 may underlie the mechanisms of ZQMT in treating AMD-related retinopathy in mice.
|
31288713 |
2019 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mean concentrations of cytokines in aqueous humour in patients with neovascular AMD before the first and third ranibizumab injections were as follows (in pg/mL): CXCL1, 8.4 and 3.3; IP-10, 110 and 55; CXCL12, 480 and 240; CXCL13, 9.2 and 2.6; MCP-1, 620 and 220; CCL11, 7.1 and 2.8; IL-6, 5.9 and 1.6; IL-10, 0.15 and 0.015 (all p<0.0001), and MMP-9, 0.92 and 1.5 (p=0.0216), respectively.
|
28765149 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the CCL2/CX3CR1 double knockout mouse model (DKO), which demonstrates RPE damage and retinal degeneration, we uncovered an interaction between PEDF and the TEP which is likely to play an important role in retinal ageing and in the pathogenesis of AMD.
|
30160348 |
2018 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linear univariate and ANCOVA modeling was performed to show the interaction of rs1024611 with another SNP variant of CCL-2/CCR-2 (rs4586 and rs1799865) and impact of individual genotypes on CCL-2 expression in the context of AMD pathology.
|
29664944 |
2018 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It has been indicated that oxidization triggers the development of AMD by inducing the dysfunction and degeneration of RPE cells, which results in the upregulation of local monocyte chemotactic protein-1 (MCP-1) expression.
|
28546942 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we explore the role of interleukin-1β (IL-1β) in modulating AMD-associated chemokines Ccl2, Cxcl1, and Cxcl10 during photo-oxidative retinal damage, and the effect on both the accumulation of outer-retinal macrophages, and death of photoreceptors.
|
28438165 |
2017 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also revealed synergistic influence of CCL2-2518 and the at-risk genotype of the C3 in AMD with an estimated AP = 50.9% (adjusted AP = 24.7%).
|
28095095 |
2017 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AG genotype of CCL2-2518 in combination with TT genotype of CFH Y402H showed significant protective effect against AMD.
|
27316788 |
2016 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The increased MCP-1 induced by oxidative damage attracts macrophages to retinas, and macrophages release pro-inflammatory factor and promote the process of AMD.
|
27812755 |
2016 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also used the Ccl2 (-/-) /Cx3cr1 (-/-) /rd8 and Ccl2 (-/-) /Cx3cr1 (gfp/gfp) mouse models with AMD-like retinal degeneration to further explore the involvement of Wnt signaling activation in the retinal lesions in those models and to preclinically evaluate the role of Wnt signaling suppression as a potential therapeutic option for AMD.
|
26476672 |
2015 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
We here show using targeted replacement mice expressing the human APOE isoforms (TRE2, TRE3, and TRE4) that MPs of TRE2 mice express increased levels of APOE, interleukin-6, and CCL2 and develop subretinal MP accumulation, photoreceptor degeneration, and exaggerated choroidal neovascularization similar to AMD.
|
26446211 |
2015 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis and are key regulator and effector cells of the local immune response to acute and chronic tissue injury.Two major signalling pathways that differentially define trafficking behaviour and activation of systemic and local myeloid cell populations in response to exogenous and endogenous inflammatory stimuli are the Ccl2-Ccr2 and the Cx3cl1-Cx3cr1 chemokine pathways.Alterations in these pathways have been implicated in controlling myeloid cell activation during normal ageing and in age-related retinal degenerations, including age-related macular degeneration (AMD).We review the evidence for how altered chemokine signalling in acute and chronic inflammatory conditions regulate local and systemic myeloid cell responses in the retina and how this may contribute to or attenuate pathology in inherited and age-related retinal diseases.
|
24664727 |
2014 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
After PBMCs were stimulated with peptidoglycan (PGN) and poly(I:C), the specific ligands of TLR2 and TLR3, cytokines interleukin-6 (IL-6), IL-8, VEGF, and monocyte chemoattractant protein-1 (MCP-1) production in 11 patients with wet AMD and 11 controls were assessed.
|
23946637 |
2013 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
CCL2/CCR2 inhibition might represent a powerful tool for controlling inflammation and neurodegeneration in AMD.
|
24142887 |
2013 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration.
|
22357958 |
2012 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The CCL2 ELISA levels were significantly higher in AMD patients and flow Cytometry analysis revealed significantly reduced CCR2 expressing PBMCs in AMD patients as compared to normal controls.
|
23185481 |
2012 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low levels of MCP-1 protein were detected in RPE from AMD smoker patients relative to controls.
|
21386905 |
2011 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigates the mechanisms for the effects of quercetin on cultured human RPE cells and in Ccl2/Cx3cr1 double knock-out (DKO) mice, which spontaneously develop progressive retinal lesions mimicking age-related macular degeneration (AMD).
|
20361964 |
2010 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
This paper reviews the possible implications of CCL2 and CX3CL1 signaling in AMD.
|
21126357 |
2010 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other murine models target genes relevant to AMD, including inflammatory genes such as Cfh(-/-), Ccl2(-/-), Ccr2(-/-), Cx3cr1(-/-), and Ccl2(-/-)/cx3cr1(-/-), oxidative stress associated genes such as Sod1(-/-) and Sod2 knockdown, metabolic pathway genes such as neprilysin(-/-) (amyloid beta), transgenic mcd/mcd (cathepsin D), Cp(-/-)/Heph(-/Y) (ferroxidase ceruloplasmin/hepaestin, iron metabolism), and transgenic ApoE4 on high fat and high cholesterol diet (lipid metabolism).
|
20206286 |
2010 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression analysis did not demonstrate altered RNA expression of CCL2 and CCR2 in the retinal pigment epithelium from AMD eyes (for CCL2 P = 0.62; for CCR2 P = 0.97).
|
18172114 |
2008 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
LHGDN |
Expression analysis did not demonstrate altered RNA expression of CCL2 and CCR2 in the retinal pigment epithelium from AMD eyes (for CCL2 P = 0.62; for CCR2 P = 0.97).
|
18172114 |
2008 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
By 6 weeks of age, all Ccl2(-/-)/Cx3cr1(-/-) mice developed AMD-like retinal lesions, including drusen, retinal pigment epithelium alteration, and photoreceptor degeneration.
|
17652758 |
2007 |