CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Disease: Secondary malignant neoplasm of omentum ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0346991
Disease: Secondary malignant neoplasm of omentum
Secondary malignant neoplasm of omentum 		0.010 Biomarker disease BEFREE Here, we show that MCP-1 produced by omental adipocytes binding to its cognate receptor CCR-2 on ovarian cancer cells facilitates migration and omental metastasis by activating the PI3K/AKT/mTOR pathway and its downstream effectors HIF-1α and VEGF-A in cell lines, xenografts, and transgenic murine models. 31705064 2020