CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Disease: Oestrogen deficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.020 AlteredExpression disease BEFREE ALA (100 and 300 mg/kg) intervention to estrogen-deficiency induced bone loss mice (ovariectomized) showed reductions in TRAP+ osteoclasts count, CTX-I expression, levels of IL-1β, IL-2, IL-6, IL10, TNF-α and MCP-1 and iNOS and COX-2. 29061958 2017
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.020 Biomarker disease BEFREE Estrogen deficiency in ArKO mice was associated with significant increases in LPS-induced serum interleukin-6 (IL-6), tumor necrosis factor, monocyte chemotactic protein 1, and interferon-gamma levels, which were significantly abrogated by administration of 16alpha-LE2, but not 8beta-VE2. 20131258 2010