To investigate the association between 3 major polymorphisms in genes encoding enzymes involved in remethylation of homocysteine to methionine--methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, and betaine homocysteine methyltransferase (BHMT) G742A--and CAD, with assessment of small-study bias and differences between studies.
Since genetic variants in folate-dependent remethylation have been reported to increase risk for cardiovascular disease and other common disorders, we screened BHMT for sequence changes that might alter risk for coronary artery disease (CAD).