|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
There was a weak and negative correlation between T-bet expression and RANTES level in the asthmatics (r=-0 x 29, P=0 x 032).
|
17302903 |
2007 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
RGD |
Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma.
|
18208670 |
2008 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
RANTES is genetically associated with asthma, sarcoidosis and multiple sclerosis.
|
16855620 |
2006 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that eosinophils play a crucial role in the pathogenesis, particularly in eosinophil and T lymphocyte recruitment into the inflamed sites in asthma through RANTES production.
|
9363922 |
1997 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although there are several reports on the association of RANTES promoter polymorphisms (-403G/A and -28C/G) with asthma, the association of these polymorphisms with atopic dermatitis has not yet been confirmed in other populations.
|
17117952 |
2006 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
CTD_human |
RANTES was also expressed in the bronchial epithelium in vivo, as indicated by positive immunocytochemical staining of bronchial biopsy tissues obtained from mild asthmatic patients before and after treatment with 500 micrograms of inhaled beclomethasone dipropionate (BDP) twice daily or matched placebo for 4 mo.
|
8534483 |
1996 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma.
|
10386610 |
1999 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection.
|
28168862 |
2017 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that -28 C/G and -403 G/A polymorphisms within the RANTES promoter region play an important role in asthma predisposition and in the severity of airway obstruction.
|
17678722 |
2007 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have evaluated the effects of doses ranging from 10 ng to 100 micro g of two CC chemokine receptor antagonists, Met-RANTES/CC chemokine ligand 5 (CCL5) and aminooxypentane-RANTES/CCL5, in preventing inflammation in the OVA-sensitized murine model of human asthma.
|
14607956 |
2003 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
LHGDN |
It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs.
|
18385174 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the CCL5 -28C/G polymorphism is a risk factor for asthma.
|
25898691 |
2015 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, RANTES is constitutively expressed in the airways and RANTES mRNA is elevated in airways of patients with mild asthma, supporting a role for RANTES in normal and asthmatic airways.
|
8970374 |
1996 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
No differences in the release or expression of RANTES, IFN-λ1 protein and mRNA, or IFN-α and IFN-β mRNA between asthmatics and healthy controls were observed.
|
29411555 |
2018 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between RANTES gene polymorphisms and asthma: a meta-analysis.
|
24963658 |
2014 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
|
17990036 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Carriers of both IL-13 A2044G A/A and RANTES G-28C G/G have a more significant risk for developing asthma than those with only a single polymorphism.
|
24053708 |
2013 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These observations support the view that atopic and nonatopic asthma are associated with combined bronchial mucosal expression of CC chemokines (RANTES and MCP-3), together with eosinophil-active cytokines (IL-5, GM-CSF, and IL-3).
|
8998072 |
1997 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied 61 patients with asthma and/or atopy and 129 to 157 newborn controls for the -403 RANTES, -28 RANTES, and -1055 IL-13 SNPs, as well as 47 patients and 60 newborn controls for the -444 LTC4S SNP.
|
16024972 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes.
|
23267209 |
2013 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Treatment with NOD1,2 ligand could induce the subepithelial fibrosis and significantly enhance the serum concentration of total IgE, chemokine CCL5 for eosinophils and T helper type 2 (Th2) cells and asthma Th2 cytokine IL-13 in bronchoalveolar lavage fluid of ovalbumin-sensitized allergic asthmatic mice (all P<0.05).
|
23524653 |
2013 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.
|
22444510 |
2012 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RANTES G-401A was not associated with physician-diagnosed asthma (P = 0.408).
|
15715189 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Asthma is a complex inherited disease.The study was undertaken to identify the association of RANTES promoter polymorphisms with atopy and asthma using family-based association tests (FBATs) and generation-specific case-control analyses.
|
15592421 |
2005 |