CCL5, C-C motif chemokine ligand 5, 6352

N. diseases: 514; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 AlteredExpression disease BEFREE The gene expression of RANTES appeared to be the same for RA SFMC, RA PBMC, and normal PBMC. 7521808 1994
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 AlteredExpression disease BEFREE Fractionation or RA ST patient samples revealed that RANTES expression was restricted to the T cells, whereas MIP-1 beta expression was detected in both T and non-T fractions. 7545093 1995
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 Biomarker disease BEFREE These studies demonstrate that by expressing the chemokines RANTES and IL-8, synovial fibroblasts may participate in the ongoing inflammatory process in rheumatoid arthritis. 7680648 1993
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.010 AlteredExpression disease BEFREE RANTES-promoter-luciferase gene fusion assays demonstrate high levels of reporter gene activity in a "mature" T cell line Hut78, the erythroleukemic cell line HEL, and the rhabdomyosarcoma cell line RD, with little or no activity in the "early" T cell line Jurkat, the gamma delta T cell line PEER, the thymic tumor Molt4, or the pre-erythroid cell line K562. 7689610 1993
CUI: C0220611
Disease: Childhood Rhabdomyosarcoma
Childhood Rhabdomyosarcoma 		0.010 AlteredExpression disease BEFREE RANTES-promoter-luciferase gene fusion assays demonstrate high levels of reporter gene activity in a "mature" T cell line Hut78, the erythroleukemic cell line HEL, and the rhabdomyosarcoma cell line RD, with little or no activity in the "early" T cell line Jurkat, the gamma delta T cell line PEER, the thymic tumor Molt4, or the pre-erythroid cell line K562. 7689610 1993
CUI: C0279550
Disease: Adult Rhabdomyosarcoma
Adult Rhabdomyosarcoma 		0.010 AlteredExpression disease BEFREE RANTES-promoter-luciferase gene fusion assays demonstrate high levels of reporter gene activity in a "mature" T cell line Hut78, the erythroleukemic cell line HEL, and the rhabdomyosarcoma cell line RD, with little or no activity in the "early" T cell line Jurkat, the gamma delta T cell line PEER, the thymic tumor Molt4, or the pre-erythroid cell line K562. 7689610 1993
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker disease CTD_human RANTES was also expressed in the bronchial epithelium in vivo, as indicated by positive immunocytochemical staining of bronchial biopsy tissues obtained from mild asthmatic patients before and after treatment with 500 micrograms of inhaled beclomethasone dipropionate (BDP) twice daily or matched placebo for 4 mo. 8534483 1996
CUI: C0085311
Disease: Diffuse cutaneous leishmaniasis
Diffuse cutaneous leishmaniasis 		0.010 AlteredExpression disease BEFREE The expression of macrophage chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1 alpha and -1 beta, RANTES (regulated on activation, normal T cell expressed and secreted), I-309, and interleukin-8 were investigated in lesions of patients with LCL or DCL. 8627035 1996
CUI: C4543948
Disease: Localized cutaneous leishmaniasis
Localized cutaneous leishmaniasis 		0.010 AlteredExpression disease BEFREE The expression of macrophage chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1 alpha and -1 beta, RANTES (regulated on activation, normal T cell expressed and secreted), I-309, and interleukin-8 were investigated in lesions of patients with LCL or DCL. 8627035 1996
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.030 AlteredExpression group BEFREE The increased number of MCP-1 and RANTES mRNA-expressing cells in mucosa from patients with IBD suggests that these cytokines play a role in the pathogenesis of mucosal inflammation. 8683390 1996
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.030 Biomarker disease BEFREE These results suggest that the genetic basis of peripheralblood eosinophilia in K-VI owl monkeys is likely a function of heightened eosinophilopoiesis and depressed recruitment kinetics from the peripheral circulatory pool in response to RANTES. 8829474 1996
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.030 Biomarker group BEFREE These results suggest that the genetic basis of peripheralblood eosinophilia in K-VI owl monkeys is likely a function of heightened eosinophilopoiesis and depressed recruitment kinetics from the peripheral circulatory pool in response to RANTES. 8829474 1996
CUI: C0149516
Disease: Chronic sinusitis
Chronic sinusitis 		0.010 Biomarker disease BEFREE Positive identification in situ of mRNA expression of IL-6, and IL-12, and the chemotactic cytokine RANTES in patients with chronic sinusitis and polypoid disease. Clinical relevance and relation to allergy. 8831850 1996
CUI: C0334108
Disease: Multiple polyps
Multiple polyps 		0.010 AlteredExpression disease BEFREE To the best of our knowledge, this is the first study that demonstrates RANTES and IL-12 on mRNA level in human sinonasal mucosa in situ. mRNA for IL-6, IL-12 and RANTES were detected in 2, 8 and 6 patients with chronic sinusitis, respectively, and in mucosa from patients with polyposis a positive expression was observed in 4, 14 and 10 cases. 8831850 1996
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.030 Biomarker phenotype BEFREE RANTES production did not alter the growth of these cytokine gene-modified tumor cells in vitro, but injection of RANTES-secreting cells resulted in the abolition of the ability of those cells to form solid tumors in vivo. 8864755 1996
CUI: C0016057
Disease: Fibrosarcoma
Fibrosarcoma 		0.010 GeneticVariation disease BEFREE Thus, the human RANTES chemokine can abolish tumorigenicity of an immunogenic fibrosarcoma in an in vivo murine model, and this process is mediated by various subpopulations of immune effector cells. 8864755 1996
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.010 GeneticVariation disease BEFREE Thus, the human RANTES chemokine can abolish tumorigenicity of an immunogenic fibrosarcoma in an in vivo murine model, and this process is mediated by various subpopulations of immune effector cells. 8864755 1996
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 Biomarker disease BEFREE These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis. 8906106 1996
CUI: C0013595
Disease: Eczema
Eczema 		0.090 Biomarker disease BEFREE These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis. 8906106 1996
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker disease BEFREE Thus, RANTES is constitutively expressed in the airways and RANTES mRNA is elevated in airways of patients with mild asthma, supporting a role for RANTES in normal and asthmatic airways. 8970374 1996
CUI: C0847614
Disease: Nasal allergies
Nasal allergies 		0.010 Biomarker phenotype BEFREE RANTES from HNECs and HMMECs likely plays a critical role in eosinophil infiltration of the nasal mucosa in subjects with nasal allergy. 8977532 1996
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.290 AlteredExpression disease BEFREE In view of its in vitro biologic activity and in vivo expression pattern, RANTES may be a pivotal mediator of the cellular infiltrate seen in graft atherosclerosis. 8981204 1996
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.080 AlteredExpression disease BEFREE In view of its in vitro biologic activity and in vivo expression pattern, RANTES may be a pivotal mediator of the cellular infiltrate seen in graft atherosclerosis. 8981204 1996
CUI: C0004096
Disease: Asthma
Asthma 		0.600 AlteredExpression disease BEFREE These observations support the view that atopic and nonatopic asthma are associated with combined bronchial mucosal expression of CC chemokines (RANTES and MCP-3), together with eosinophil-active cytokines (IL-5, GM-CSF, and IL-3). 8998072 1997
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.030 Biomarker disease BEFREE RANTES in human allergen-induced rhinitis: cellular source and relation to tissue eosinophilia. 9032215 1997