CCL5, C-C motif chemokine ligand 5, 6352

N. diseases: 514; N. variants: 6
Disease: Late onset asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264413
Disease: Late onset asthma
Late onset asthma 		0.020 GeneticVariation disease BEFREE It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs. 18385174 2008
CUI: C0264413
Disease: Late onset asthma
Late onset asthma 		0.020 GeneticVariation disease BEFREE Our findings suggest that, among Japanese, the -28G allele of the RANTES promoter region confers susceptibility to late-onset asthma. 12204866 2002