|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We studied the correlation between the eotaxin gene expression level in the material from nasal brushing and respiratory tests in asthma and COPD patients.
|
22846146 |
2012 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and a murine model of asthma.
|
26810221 |
2016 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Budesonide inhibited airway hyperreactivity, eosinophil counts in the lung and bronchoalveolar lavage (BAL) and CCL11, IL-13, and IL-23p19 release in the BAL of mice sensitized and challenged with <i>Af</i> (<i>p</i> < 0.05).
|
31572383 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity.
|
29423947 |
2018 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry showed increased expression of both eotaxin-2 and eotaxin-3 in addition to eotaxin-1 in asthmatics.
|
14698143 |
2003 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α).
|
29297467 |
2019 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma.
|
17845580 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here, we used NMR and fluorescence anisotropy to study the interaction between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma response.
|
24482230 |
2014 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results of this study suggest that ASM may contribute to airway inflammation in asthma through the production and release of eotaxin.
|
10351942 |
1999 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CCL11 SNPs and haplotypes were not associated with asthma among white or Hispanic families.
|
16461130 |
2006 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Asthmatics with glutathione S-transferase P1 Val(105)/Val(105) compared with asthmatics with the glutathione S-transferase P1 Val(105)/Ile(105) and Ile(105)/Ile(105) had greater generation of acute phase cytokines (TNF-α, IL-6, CXCL8), IL-12, CCL11, thromboxane B2 and immunoglobulin E at 24 h after local allergen challenge.
|
23600543 |
2013 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma.
|
12045241 |
2002 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results indicate that IL-13 and IL-4 cause eotaxin release in HASM cells through a mechanism that, in part, involves ERK activation and suggest that the smooth muscle may be an important source of chemokines leading to eosinophil recruitment in asthma.
|
11880312 |
2002 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the polymorphisms of the eotaxin gene family are associated with the susceptibility of asthma and Eotaxin-3 might play the critical role for the recruitment of eosinophils and the maintenance of IgE levels.
|
15207712 |
2004 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together, these cells release a plethora of mediators including interleukin (IL)-4, IL-5, granulocyte/macrophage colony-stimulating factor and eotaxin which ultimately cause the histopathology and symptoms of asthma.
|
10730545 |
2000 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Sputum eotaxin and IL-4 concentrations in luteal phase were increased in PMA patients when compared with non-PMA asthmatics (P=0.016; P=0.041, respectively) and healthy subjects (P<0.001 both cytokines).
|
28840001 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Eosinophil numbers, eosinophil cationic protein (ECP), and the expression of eotaxin were examined in induced sputum from atopic asthmatics (AA = 11), nonatopic asthmatics (NAA = 11), and atopic (AC = 12) and normal (NC = 10) controls.
|
11097314 |
2000 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Eotaxin is a member of the C-C family of chemokines and is related during antigen challenge in a guinea pig model of allergic airway inflammation (asthma).
|
7869037 |
1995 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Eotaxin variation/haplotype information identified in this study might provide valuable insights into strategies for the control of asthma.
|
12761043 |
2003 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Such mice demonstrate that eotaxin enhances the magnitude of the early (but not late) eosinophil recruitment after antigen challenge in models of asthma and stromal keratitis.
|
9034156 |
1997 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that: 1) Asthmatic HBEC exhibit an exaggerated apical, but not basal, secretion of TSLP after dsRNA exposure; 2) TSLP exposure induces unidirectional (apical) secretion of CCL11/eotaxin-1 in asthmatic HBEC and enhanced CCL11/eotaxin-1 secretion in asthmatic HASMC; 3) Rhinovirus-induced asthma exacerbations in children are associated with in vivo airway secretion of TSLP and CCL11/eotaxin-1.
|
25546419 |
2014 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Eotaxin was expressed by bone marrow cells from all 3 groups, but there was no increase in subjects with asthma.
|
9893192 |
1999 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The detection of statistical interaction models is one evidence of gene-gene interactions among Eotaxin genes, and this interaction is thought to influence the development of asthma.
|
18712274 |
2008 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results may suggest that eotaxin could be involved in the increased smooth muscle mass observed in asthmatics through the activation of CCR3.
|
16081847 |
2005 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that Th2 cytokines and TGF-beta may contribute to the pathogenesis of asthma by stimulating expression of CCL11.
|
20214667 |
2010 |