CCL11, C-C motif chemokine ligand 11, 6356

N. diseases: 250; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease CTD_human
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease HPO
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.310 Biomarker group CTD_human
CUI: C4505456
Disease: HIV Coinfection
HIV Coinfection 		0.300 Biomarker disease CTD_human
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease BEFREE Eotaxin is a member of the C-C family of chemokines and is related during antigen challenge in a guinea pig model of allergic airway inflammation (asthma). 7869037 1995
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.100 AlteredExpression disease BEFREE The identification of constitutive eotaxin mRNA expression in multiple tissues suggests that in addition to regulating airway eosinophilia, eotaxin is likely to be involved in eosinophil recruitment into other tissues as well as in baseline tissue homing. 7869037 1995
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 AlteredExpression group BEFREE The identification of constitutive eotaxin mRNA expression in multiple tissues suggests that in addition to regulating airway eosinophilia, eotaxin is likely to be involved in eosinophil recruitment into other tissues as well as in baseline tissue homing. 7869037 1995
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease BEFREE Eotaxin is an eosinophil-specific chemoattractant that has been recently identified in rodent models of asthma and host response against tumors. 8597956 1996
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.100 Biomarker disease BEFREE These results now provide a mechanism involving eotaxin to explain the eosinophil infiltration seen in a variety of human disease; as such, an eotaxin antagonist may be a novel therapy for certain human diseases characterized by tissue eosinophilia. 8597956 1996
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.100 Biomarker disease BEFREE This data suggests that the development of tissue eosinophilia in vivo involves a two-step mechanism elicited by interleukin 5 and eotaxin. 8784786 1996
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 Biomarker group BEFREE This data suggests that the development of tissue eosinophilia in vivo involves a two-step mechanism elicited by interleukin 5 and eotaxin. 8784786 1996
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 Biomarker group BEFREE These results now provide a mechanism involving eotaxin to explain the eosinophil infiltration seen in a variety of human disease; as such, an eotaxin antagonist may be a novel therapy for certain human diseases characterized by tissue eosinophilia. 8597956 1996
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE Eotaxin messenger RNA accumulates markedly in the lesions of patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease), but not in the lesions of patients with diverticulitis. 8597956 1996
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Eotaxin is an eosinophil-specific chemoattractant that has been recently identified in rodent models of asthma and host response against tumors. 8597956 1996
CUI: C0034068
Disease: Pulmonary Eosinophilia
Pulmonary Eosinophilia 		0.060 Biomarker disease BEFREE Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. 8784786 1996
CUI: C0340076
Disease: Asthmatic pulmonary eosinophilia
Asthmatic pulmonary eosinophilia 		0.050 Biomarker disease BEFREE Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. 8784786 1996
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 Biomarker disease BEFREE Eotaxin messenger RNA accumulates markedly in the lesions of patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease), but not in the lesions of patients with diverticulitis. 8597956 1996
CUI: C0012813
Disease: Diverticulitis
Diverticulitis 		0.010 Biomarker disease BEFREE Eotaxin messenger RNA accumulates markedly in the lesions of patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease), but not in the lesions of patients with diverticulitis. 8597956 1996
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease BEFREE Such mice demonstrate that eotaxin enhances the magnitude of the early (but not late) eosinophil recruitment after antigen challenge in models of asthma and stromal keratitis. 9034156 1997
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease BEFREE The increase in number of cells expressing eotaxin mRNA correlated with the number of eosinophils in the bronchial tissue and with two major clinical and functional indices of disease severity, suggesting that eotaxin is involved in the recruitment of eosinophils and in eosinophil-induced tissue damage in asthma. 9240429 1997
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.100 Biomarker disease BEFREE These results indicate a contributory role for eotaxin in the generation of peripheral blood and antigen-induced tissue eosinophilia. 9034156 1997
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 Biomarker group BEFREE These results indicate a contributory role for eotaxin in the generation of peripheral blood and antigen-induced tissue eosinophilia. 9034156 1997
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.080 AlteredExpression disease BEFREE Increased eotaxin-mRNA expression in non-atopic and atopic nasal polyps: comparison to RANTES and MCP-3 expression. 9532637 1997
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.050 AlteredExpression disease BEFREE The numbers of cells expressing eotaxin mRNA were also determined after either allergen or diluent challenge in atopic subjects with a history of allergic rhinitis. 9409555 1997
CUI: C0018621
Disease: Hay fever
Hay fever 		0.020 AlteredExpression disease BEFREE Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. 9409555 1997