BID, BH3 interacting domain death agonist, 637

N. diseases: 117; N. variants: 5
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE Patients with BRAFV600 mutated melanoma with BM were enrolled into cohort 1 (previously untreated BM) and cohort 2 (previously treated BM) and received vemurafenib (960 mg BID) until disease progression (PD) or intolerance. 27993793 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.030 GeneticVariation disease BEFREE In a Phase I study (BRIM-1), a 960-mg BID dose achieved an objective response rate of 81% among 32 patients with melanoma who carried a BRAF V600E mutation. 22742884 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease LHGDN Activation of caspases and cleavage of Bid are required for tyrosine and phenylalanine deficiency-induced apoptosis of human A375 melanoma cells. 12061801 2002