Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, we provide <i>in vivo</i> evidence that CX3CL1 is a strong activator of adult neurogenesis, reduces neuronal loss, and improves cognitive function in Alzheimer's disease.<b>Significance Statement:</b> This study will be the first to demonstrate the enhanced neurogenesis by overexpressed CX3CL1 is mitigated by disruption of Smad2 signaling and independent of its interaction with CX3CR1.
|
31822518 |
2020 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These differential effects may explain recent studies reporting seemingly conflicting results regarding the effect of FKN over expression on AD pathologies.
|
30744705 |
2019 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we review the expression, distribution, and function of CD200, CX3CL1, and TREM2 in regulating neuron-microglia interactions under physiological conditions as well as in AD.
|
29729150 |
2018 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The CX3CL1 expression increased in endothelial and abluminal compartments with PBMCs from mild AD patients compared to controls.
|
30092003 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects.
|
30245615 |
2018 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cox regression models showed adverse effects of high CX3CL1 levels only in AD patients with smoking history (hazard ratio = 3.01, p = 0.034), but not in AD patients without smoking history or in SQ patients with smoking history.
|
29380447 |
2018 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of CX3CR1, CX3CL1 and the microglial phagocytic phenotype were studied in brain tissue samples from AD patients.
|
28810892 |
2017 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We start with summarizing several immune pathways, involving complements, MHC-I and CX3CL1, which mediate synaptic elimination during development and in AD.
|
28372329 |
2017 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In models of Alzheimer's disease (AD), multiple sclerosis (MS) and neurotoxin models of PD, the chemokine CX3CL1 (fractalkine) and its receptor (CX3CR1) have important roles in modulating neuroinflammation.
|
26469270 |
2015 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, CX3CL1 should be considered as promising additional marker for the early diagnosis of AD and underlines once more, the involvement of the neuroinflammation in the pathogenesis of this neurodegenerative disease.
|
25596843 |
2015 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings demonstrated that CX3CL1 plays a neuroprotective role in 6-OHDA-induced dopaminergic lesion and it might be an effective therapeutic target for many neurodegenerative diseases, including Parkinson disease and Alzheimer disease, where inflammation plays an important role.
|
21266082 |
2011 |