BIK, BCL2 interacting killer, 638

N. diseases: 48; N. variants: 5
Disease: Adult Synovial Sarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278660
Disease: Adult Synovial Sarcoma
Adult Synovial Sarcoma 		0.010 PosttranslationalModification disease BEFREE Quisinostat inhibits aggresome formation in response to proteasome inhibition, and combination treatment leads to elevated endoplasmic reticulum stress, activation of pro-apoptotic effector proteins BIM and BIK, phosphorylation of BCL-2, increased levels of reactive oxygen species, and suppression of tumor growth in a murine model of synovial sarcoma. 28056055 2017