|
Glioma
|
0.280 |
Biomarker
|
disease |
BEFREE |
This work demonstrates that BCAN-NTRK1 is a bona fide human glioma driver and describes a general strategy to define the oncogenic potential of novel glioma-associated genomic rearrangements and to generate accurate preclinical models of this lethal human cancer.
|
28695888 |
2017 |
|
Glioma
|
0.280 |
AlteredExpression
|
disease |
BEFREE |
Brain Enriched Hyaluronan Binding (BEHAB)/brevican (B/b), is a CNS-specific ECM constituent and is upregulated in the glioma TME.
|
25052349 |
2014 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
BEFREE |
Surprisingly, HAPLN4 increased glioma cell adhesion and migration and even potentiated the motogenic effect of brevican.
|
19633295 |
2009 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
LHGDN |
Moreover, the N-terminal cleavage product of brevican, but not the full-length protein, associates with fibronectin in cultured cells and in surgical samples of glioma.
|
18611854 |
2008 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
BEFREE |
Moreover, the N-terminal cleavage product of brevican, but not the full-length protein, associates with fibronectin in cultured cells and in surgical samples of glioma.
|
18611854 |
2008 |
|
Glioma
|
0.280 |
AlteredExpression
|
disease |
LHGDN |
These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican.
|
16133547 |
2005 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
BEFREE |
These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican.
|
16133547 |
2005 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
RGD |
In addition, B/b130 is the major isoform of BEHAB/brevican that is up-regulated in a rat model of invasive glioma and may therefore contribute to the invasive ability of glioma cells.
|
12799382 |
2003 |
|
Glioma
|
0.280 |
ModifyingMutation
|
disease |
RGD |
It will be important to investigate the effect of inhibiting cleavage of BEHAB/brevican in these cells and to determine the therapeutic potential of inhibiting BEHAB/brevican cleavage in gliomas.
|
11585735 |
2001 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
BEFREE |
The distinct patterns of regulation of expression of the two isoforms suggest distinct mechanisms of regulation of BEHAB/brevican during development and in glioma.
|
11054543 |
2000 |
|
Glioma
|
0.280 |
AlteredExpression
|
disease |
BEFREE |
BEHAB/brevican mRNA is expressed in the ventricular zone coincident with the initial proliferation and migration of glial cells and in surgical samples of human glioma, where glial-derived cells proliferate and migrate.
|
10364444 |
1999 |
|
Glioma
|
0.280 |
Biomarker
|
disease |
BEFREE |
The noninvasive 9L glioma cell was transfected with either full-length BEHAB/brevican or the HABD and tested for invasion in in vitro and in vivo invasion assays.
|
9502798 |
1998 |
|
Malignant Glioma
|
0.210 |
Biomarker
|
disease |
BEFREE |
Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas.
|
16061654 |
2005 |
|
Malignant Glioma
|
0.210 |
Biomarker
|
disease |
RGD |
A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma.
|
12799382 |
2003 |
|
Malignant Glioma
|
0.210 |
ModifyingMutation
|
disease |
RGD |
Brain enriched hyaluronan binding (BEHAB)/brevican increases aggressiveness of CNS-1 gliomas in Lewis rats.
|
11585735 |
2001 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Biomarker
|
disease |
RGD |
Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex.
|
15869933 |
2005 |
|
Hypoxia-Ischemia, Brain
|
0.200 |
Biomarker
|
disease |
RGD |
The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2.
|
15817274 |
2005 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican.
|
16133547 |
2005 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Cleavage of the BEHAB/brevican protein may increase invasion of tumor cells.
|
9811619 |
1998 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The noninvasive 9L glioma cell was transfected with either full-length BEHAB/brevican or the HABD and tested for invasion in in vitro and in vivo invasion assays.
|
9502798 |
1998 |
|
oligodendroglioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We report that the BCAN, CSPG4, IGF2BP3, PTPRZ1 and TNC proteins are significantly over-expressed at the mRNA (n = 159) and protein (n = 36) levels in grade II/III glioma patients as compared to non-tumor samples (IGF2BP3 being absent from oligodendroglioma).
|
29308320 |
2018 |
|
Well Differentiated Oligodendroglioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We report that the BCAN, CSPG4, IGF2BP3, PTPRZ1 and TNC proteins are significantly over-expressed at the mRNA (n = 159) and protein (n = 36) levels in grade II/III glioma patients as compared to non-tumor samples (IGF2BP3 being absent from oligodendroglioma).
|
29308320 |
2018 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
It is possible that lecticans, particularly brevican, inhibit synaptic plasticity in this model of AD.
|
26337292 |
2015 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
As proteoglycans stabilize synaptic structure and inhibit molecular plasticity, defective brevican processing observed in Abeta-bearing mice and potentially end-stage human AD, may contribute to deficient neural plasticity.
|
20180882 |
2010 |