SDC2, syndecan 2, 6383

N. diseases: 120; N. variants: 0
Disease: Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 Biomarker disease BEFREE As one of miR-20a-5p's targets, SDC2 was found to mediate the miR-20a-5p-induced repression of OS chemoresistance. 29118673 2017
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 Biomarker disease BEFREE We previously showed that Wnt/β-catenin/T-cell factor (TCF) activation are responsible for the repression of syndecan-2, a key modulator of apoptosis and chemosensitivity in osteosarcoma cells, suggesting a role of Wnt signaling in chemoresistance. 22550000 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 AlteredExpression disease BEFREE We identified a DNA region that negatively regulates syndecan-2 transcription in the osteosarcoma cells. 20530678 2010
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 AlteredExpression disease BEFREE In addition, overexpression of syndecan-2 sensitized human osteosarcoma cells to chemotherapy-induced apoptosis, increasing the response to methotrexate, doxorubicin, and cisplatin. 17440083 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 Biomarker disease BEFREE In this study, we examined the role of syndecan-2 in osteosarcoma cell proliferation and apoptosis. 15936998 2005