HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results indicate that genetic background involving CCR5, CCR2 and SDF-1 alleles may play a limited role in the natural history of HIV-1 infection.
|
11693435 |
2002 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in genes encoding chemokine receptors and their ligands, viz., CCR5delta32, CCR2-64I and SDF1-3'A are implicated to have protective effects against HIV-1 infection and/or disease progression.
|
17240189 |
2007 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, other mutations in the CCR5, CCR2, CX(3)CR1, CXCL12 (SDF1), and CCL5 (RANTES) genes have been identified and associated with host resistance and/or susceptibility to HIV-1 infection and disease progression.
|
17504215 |
2007 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the encoding genes, such as CCR5-∆32, CCR2-64I and SDF1-3'A are shown to result in protective effects against HIV-1 infection and disease progression.
|
21667221 |
2012 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results underscore the global distribution of the SDF1 polymorphism and the hypothesis that the SDF1-3'A allele, itself, may not be sufficient to prevent the risk of HIV-1 infection and may be not related to the progression of the disease in the Brazilian population.
|
16611258 |
2006 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SDF1-3'A did not differ between HIV-seropositive and HIV-seronegative individuals but was associated with increasing age among HIV-seronegative women, suggesting a protective effect against HIV-1 infection.
|
16123688 |
2005 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analysed the distribution of SNPs in chemokines (CCL3, CCL4, CCL5, CXCL12) and chemokine receptor (CXCR6) genes, in 268 HIV-1 infected patients (HIV-1+) and 221 healthy controls from Northeast Brazil, and their possible connection with susceptibility to HIV-1 infection.
|
26785888 |
2016 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, cAMP did significantly reduce CXCR4 internalization rates and thereby increased the fraction of the total CXCR4 pool expressed on the cell surface. cAMP-induced increases in CXCR4 expression counteracted SDF-1-induced receptor internalization and enhanced both chemotactic response to SDF-1 and cellular vulnerability to HIV-1 infection.
|
9973394 |
1999 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the correlation of CCR5-Delta32, CCR2b-64I, and SDF1-3'A polymorphisms with susceptibility to HIV-1 infection through sexual transmission in Han Chinese.
|
18928397 |
2008 |
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The level of SDF-1 expression in PBMC did not correlate with the magnitude of CD8+ T-cell-mediated suppression of HIV-1 among ACs SDF-1 inhibited HIV-1 replication at the viral entry step, whereas a single-cycle HIV-1 infection system showed that the major part of the CD8+ T-cell-mediated suppression occurs after intracellular penetration of the virus.
|
9601514 |
1998 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the CCR5-Delta32, CCR2-64I and SDF1-3'A variants may have limited effect on protecting from HIV-1 infection in Uighurs.
|
19958843 |
2010 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations at CCR5 (CCR5-delta2), CCR2 (CCR2-641), and stromal-derived factor SDF1 (SDF1-3'A), a primary ligand for CXCR4, are known to have protective effects against HIV-1 infection and the onset of AIDS symptoms.
|
11175286 |
2000 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The low viral activity in SDF1-+/+ LTNPs suggests that other factors play a major role in vivo in determining the course of HIV-1 infection.
|
10395841 |
1999 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single-nucleotide polymorphism of CXCL12 G801A has been described and investigated in human immunodeficiency virus-1 (HIV-1) infection and in the susceptibility to several cancers.
|
21298365 |
2012 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that the CCR5-Delta32, CCR2-64I and SDF1-3'A polymorphisms have protective effects against HIV-1 infection and can delay the progression of AIDS in European populations.
|
19669591 |
2010 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of genetic variants of Stromal cell-Derived Factor 1 in pediatric HIV-1 infection and disease progression.
|
22962615 |
2012 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the prevalence of genetic variations in CCR2, SDF1, and the CCR5 gene and its promoter region at positions 59029, 59353, and 59356 in a seroprevalent cohort of 1057 children with symptomatic HIV-1 infection in the United States.
|
15076247 |
2004 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association with CCR2b-V64I (17%) and SDF1-3'A (2%) variants was determined in relation to HIV-1 infection in Gabonese patients.
|
25592723 |
2015 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SDF1-3'A SNP was associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12.
|
16284526 |
2005 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 infection, cancer, leukemia, and rheumatoid arthritis.
|
30772128 |
2019 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Protective effect of CCR5 delta 32 heterozygosity is restricted by SDF-1 genotype in children with HIV-1 infection.
|
11504955 |
2001 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significantly higher frequency of SDF1-3'A/SDF1-3'A was observed in high risk STD patients as compared to HIV seropositive (p=0.014) and healthy HIV-1 seronegative tested individuals (p=0.001), suggesting a protective role of SDF1-3'A in HIV-1 infection.
|
18775666 |
2008 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To identify additional alleles that may influence HIV-1 infection and progression to AIDS, nine SNPs (including rs1801157) spanning 20.2 kb in and around the SDF-1 gene were genotyped in over 3000 African American (AA) and European American (EA) participants enrolled in five longitudinal HIV-1/AIDS natural cohort studies.
|
16177829 |
2005 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we describe the association of the SDF1-3'A polymorphism with HIV-1 infection only in women, but not to CD4+ T-lymphocyte categories, viral load levels in patients with HIV-1/AIDS, or to exposure levels in female sex workers.
|
26859597 |
2015 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four mutational variants, CCR5-delta32, CCR5-P1, CCR2-641 and SDF1-3'A were discovered to play a regulatory role in HIV-1 infection, in the rate of progression to AIDS or both.
|
11138790 |
2000 |