HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 infection, cancer, leukemia, and rheumatoid arthritis.
|
30772128 |
2019 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For risks of infection, no evidences indicated SDF1 polymorphism was associated with the risk of HIV-1 infection in all genetic models (recessive model: OR = 0.94, 95% Cl: 0.75-1.17; homozygous model: OR = 0.89, 95% Cl: 0.70-1.15; heterozygous model: OR = 1.06, 95% Cl: 0.83-1.35; allele model: OR = 0.95, 95% Cl: 0.79-1.13), Furthermore, we failed to find an delayed AIDS progression except in some specific cohorts including MACS cohorts (RH = 0.38, 95% Cl: 0.17-0.59 for time to AIDS; RH = 0.27, 95% Cl: 0.07-0.46 for time to death at the study entry).
|
29420545 |
2018 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analysed the distribution of SNPs in chemokines (CCL3, CCL4, CCL5, CXCL12) and chemokine receptor (CXCR6) genes, in 268 HIV-1 infected patients (HIV-1+) and 221 healthy controls from Northeast Brazil, and their possible connection with susceptibility to HIV-1 infection.
|
26785888 |
2016 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association with CCR2b-V64I (17%) and SDF1-3'A (2%) variants was determined in relation to HIV-1 infection in Gabonese patients.
|
25592723 |
2015 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we describe the association of the SDF1-3'A polymorphism with HIV-1 infection only in women, but not to CD4+ T-lymphocyte categories, viral load levels in patients with HIV-1/AIDS, or to exposure levels in female sex workers.
|
26859597 |
2015 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Considering the different route of HIV-1 transfection between two subgroups, we speculate that SDF1 may contribute susceptibility to HIV-1 infection in the route of sexual intercourse.
|
26168882 |
2015 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The correlation of SDF1-3'A and CCR5 promoter CCR5-58934G/T, CCR5-59029G/A, CCR5-59353T/C, CCR5-59402 A/G and CCR5-59653C/T polymorphisms and protection to HIV-1 infection and progression to AIDS was found to be nonsignificant.
|
26096543 |
2015 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed the CCR5 59029A/G, CCR2 64I and SDF1 3'-A were not associated with host's resistance to HIV-1 infection.
|
24650919 |
2014 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the encoding genes, such as CCR5-∆32, CCR2-64I and SDF1-3'A are shown to result in protective effects against HIV-1 infection and disease progression.
|
21667221 |
2012 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single-nucleotide polymorphism of CXCL12 G801A has been described and investigated in human immunodeficiency virus-1 (HIV-1) infection and in the susceptibility to several cancers.
|
21298365 |
2012 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of genetic variants of Stromal cell-Derived Factor 1 in pediatric HIV-1 infection and disease progression.
|
22962615 |
2012 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the CCR5-Delta32, CCR2-64I and SDF1-3'A variants may have limited effect on protecting from HIV-1 infection in Uighurs.
|
19958843 |
2010 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that the CCR5-Delta32, CCR2-64I and SDF1-3'A polymorphisms have protective effects against HIV-1 infection and can delay the progression of AIDS in European populations.
|
19669591 |
2010 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CCR2-64I allele and especially the SDF1-3'A allele are predominant in the Bahraini population and may be associated with resistance to fast HIV-1 infection in Bahrainis, and thus their genotyping can be used for prognosis in HIV-infected individuals.
|
19803715 |
2009 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the correlation of CCR5-Delta32, CCR2b-64I, and SDF1-3'A polymorphisms with susceptibility to HIV-1 infection through sexual transmission in Han Chinese.
|
18928397 |
2008 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significantly higher frequency of SDF1-3'A/SDF1-3'A was observed in high risk STD patients as compared to HIV seropositive (p=0.014) and healthy HIV-1 seronegative tested individuals (p=0.001), suggesting a protective role of SDF1-3'A in HIV-1 infection.
|
18775666 |
2008 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in genes encoding chemokine receptors and their ligands, viz., CCR5delta32, CCR2-64I and SDF1-3'A are implicated to have protective effects against HIV-1 infection and/or disease progression.
|
17240189 |
2007 |
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, other mutations in the CCR5, CCR2, CX(3)CR1, CXCL12 (SDF1), and CCL5 (RANTES) genes have been identified and associated with host resistance and/or susceptibility to HIV-1 infection and disease progression.
|
17504215 |
2007 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results underscore the global distribution of the SDF1 polymorphism and the hypothesis that the SDF1-3'A allele, itself, may not be sufficient to prevent the risk of HIV-1 infection and may be not related to the progression of the disease in the Brazilian population.
|
16611258 |
2006 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A longitudinal study was conducted to evaluate the association of the SDF1 polymorphism and the progression of HIV-1 infection in 161 asymptomatic patients infected with HIV-1 (ASYMPT) and 617 patients with AIDS (SYMPT) from Londrina and the surrounding region, southern Brazil.
|
16964435 |
2006 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SDF1-3'A did not differ between HIV-seropositive and HIV-seronegative individuals but was associated with increasing age among HIV-seronegative women, suggesting a protective effect against HIV-1 infection.
|
16123688 |
2005 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SDF1-3'A SNP was associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12.
|
16284526 |
2005 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To identify additional alleles that may influence HIV-1 infection and progression to AIDS, nine SNPs (including rs1801157) spanning 20.2 kb in and around the SDF-1 gene were genotyped in over 3000 African American (AA) and European American (EA) participants enrolled in five longitudinal HIV-1/AIDS natural cohort studies.
|
16177829 |
2005 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years.
|
16249700 |
2005 |
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SDF-1 gene polymorphism, known as SDF1-3'A, has been investigated in HIV-1 infection and the incidence of breast cancer.
|
15978329 |
2005 |