CXCL12, C-X-C motif chemokine ligand 12, 6387

N. diseases: 626; N. variants: 21
Disease: Endometrial Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.060 AlteredExpression disease BEFREE Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells. 28402926 2017
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.060 AlteredExpression disease BEFREE Smoking is also associated with decreased rates of endometrial cancer and endometriosis; increased CXCL12 and FGF2 are implicated in both conditions. 28285568 2017
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.060 Biomarker disease BEFREE Stroma-derived factor-1 (SDF-1) and its receptor C-X-C chemokine receptor-4 (CXCR4) are involved in human endometrial carcinoma (EC) progression. 28239742 2017
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.060 Biomarker disease BEFREE Reciprocal crosstalk between endometrial carcinoma and mesenchymal stem cells via transforming growth factor-β/transforming growth factor receptor and C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4 aggravates malignant phenotypes. 29383153 2017
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.060 GeneticVariation disease BEFREE Our finding suggest that there was no significant association between the (SDF-1) and CXCR4 polymorphisms and endometrium cancer risk. 21607621 2012
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.060 Biomarker disease BEFREE CXCL12 is an estrogen-regulated gene, and notably, estrogen is a major risk factor for endometrial cancer (EC) development. 22025313 2012