ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
A., Chen, H., Poznansky, M. C. Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment.
|
30802149 |
2019 |
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CXCL12 and CXCR4 expressions were increased in OC tissues, particularly in the metastatic OC tissues.
|
30191987 |
2019 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), breast cancer metastasis suppressor 1 (BRMS1), astrocyte elevated gene 1 (AEG1), depending on the status of BRCA1 protein, in patients suffering from OC and BC with brain metastases.
|
30822630 |
2019 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXCL12 and CCL21 were associated with poor OS in <i>TP53</i>WT serous OC.
|
30181917 |
2018 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, it is generally believed that blocking the CXCR4/CXCL12 pathway could serve as a potential therapy for patients with ovarian cancer.
|
28753202 |
2017 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study suggested that miR-9 may function as a promising tumor inhibitor for ovarian cancer through targeting the SDF-1/CXCR4 pathway.
|
28413458 |
2017 |
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that miR-448 functions as a tumor suppressor in ovarian cancer, which exerts its activity by suppressing the expression of CXCL12.
|
26103953 |
2015 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Signals mediated by the chemokine CXCL12 and its receptor CXCR4 are involved in the progression of ovarian cancer through enhancement of tumor angiogenesis and immunosuppressive networks that regulate dissemination of peritoneal metastasis and development of cancer-initiating cells (CICs).
|
25320277 |
2014 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicated that SDF-1 might promote the invasion and metastasis of ovarian cancer by regulating these two integrin molecules.
|
24762228 |
2013 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies establish a molecular imaging reporter system for analyzing CXCL12-CXCR4 signaling in ovarian cancer, which can be used to investigate biology and therapeutic targeting of this pathway in cell-based assays and living mice.
|
23372646 |
2013 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consequently, our findings will provide a new explanation about how SDF-1 aggravates the pathogenesis of ovarian cancer.
|
23615713 |
2013 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, COX2 inhibition also blocked CXCL12 production in the ovarian cancer environment and its ability to attract MDSCs.
|
22025564 |
2011 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
We monitored CXCL12-CXCR4 binding and inhibition in a mouse xenograft model of metastatic human ovarian cancer by imaging Gaussia luciferase complementation and assessed tumor progression with firefly luciferase.
|
22241961 |
2011 |
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we report that CXCR4 and SDF-1 are expressed in OC cell lines.
|
15921680 |
2005 |
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
LHGDN |
These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer.
|
15921680 |
2005 |