Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that the CXCL12 receptor CXCR4 is highly expressed in both human primary tumors and metastases.
|
30700545 |
2019 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The CXCR4/CXCL12 axis plays prominent roles in tumor metastasis and inflammation.
|
30981691 |
2019 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
It is documented that CXCR4 signaling supports tumor metastasis formation in tissues where CXCL12, its cognate ligand, is abundant.
|
30787324 |
2019 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The CXCL12-CXCR4 signaling axis plays a key role in cancer metastasis and is a potential target for developing novel therapeutics against metastatic cancer.
|
31724498 |
2019 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of macrophage markers (CD163, CCL2/CCR2, CSF1/CSFR1, CXCR4/CXCL12), protumorigenic toll-like receptor pathway genes (CD14/TLR-1,-2,-4,-5,-6/MyD88), HLA-E, ecto-nuclease CD73/NT5E and inhibitory complement receptors (CD-59,-55,-46) remained high in metastases and represent potential therapeutic targets.
|
30203045 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Another factor explaining the osteotropism of CSCs is their ability to recognize chemokine gradients toward BM, through the CXCL12-CXCR4 axis, also known to be involved in tumor metastasis to other organs.
|
29461491 |
2018 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CXCR4 was more expressed in PT than in metastases (p = 0.0067), whereas CXCL12 was highly expressed in metastatic lesions located in liver and lung (p < 0.0001), as reported for human breast cancer.
|
30012106 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCL12 is deeply involved in the process of tumor metastasis and T-cell homing, which is driven by a chemokine gradient, but healthy bones are supposed to preferentially express CXCL12.
|
29735547 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.
|
28423491 |
2017 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, silencing of CXCL12 in TGFβ-unresponsive MSCs restored their ability to promote tumour metastasis.
|
27669436 |
2017 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although this study will need further in vivo validation, our observations suggest that (a) silencing of CXCL12 in cervical cancer cells may be critical in migration and invasion, the key events in cancer cell metastases; (b) cervical cancer cells having down regulated CXCL12 are more prone to being attracted to CXCL12 expressed at secondary sites of metastases; and (c) CXCL12 inhibits anchorage independent cell growth via anoikis.
|
26970955 |
2016 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, blocking the interaction between CXCR4 and SDF-1 could alter the tumor's metastatic phenotype and control the development and progression of cancers.
|
25978539 |
2015 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we show that stromal cell-derived factor-1 (SDF-1/CXCL12) is highly expressed in active MM, as well as in BM sites of tumor metastasis and report on the discovery of the high-affinity anti-SDF-1 PEGylated mirror-image l-oligonucleotide (olaptesed-pegol).
|
25263552 |
2014 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the CXCL12/CXCR4 axis has emerged as a key mediator of tumor metastasis; therefore, the possibility that identification of CXCR4 inhibitors can be a promising strategy for abrogating metastasis has been considered.
|
25407882 |
2014 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Physiological gradient formation within the device facilitated interrogation of key differences in chemotaxis among CXCL12 isoforms and suggests CXCL12-γ as a biomarker for metastatic cancer.
|
24675873 |
2014 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Given the demonstrated importance of CXCL12/SDF-1 in angiogenesis and tumour metastasis, we hypothesized that CXCR7 may also play a role in tumour pathogenesis.
|
23244149 |
2012 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association between SDF1-3'A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases.
|
23053994 |
2012 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Mesenchymal stromal cells (MSCs) in bone marrow may enhance tumor metastasis through secreting stromal cell-derived factor-1 (SDF-1).
|
21906874 |
2011 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicate that CXCR4-CXCL12 axis and its cross-talking with VEGF plays a role in uveal melanoma metastases and may be new prognostic markers in UMM.
|
20036848 |
2010 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCL12 immunopositivity was negatively associated with distant metastases and tumour grade.
|
20386750 |
2010 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
An exception is the angiogenic ELR(-)CXC chemokine stromal cell-derived factor-1 (CXCL12/SDF-1), which binds to CXCR4 and CXCR7 and is implicated in tumor metastasis.
|
18579287 |
2008 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
We sought to determine the role for anoikis in limiting tumor metastasis following reexpression of CXCL12 in human colorectal carcinoma cells.
|
18558091 |
2008 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using RT-PCR analysis and Western blotting, we demonstrated CXCR4 and CXCL12 expression in CRC and CRC metastases.
|
16125170 |
2005 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The ability of Kp-10 to inhibit signaling and chemotaxis induced by SDF-1 indicates that activation of GPR54 signaling may negatively regulate the role of CXCR4 in programming tumor metastasis.
|
16288036 |
2005 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The chemokine CXCL12 (SDF-1) and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies.
|
15363550 |
2004 |