Disease: Mechanical pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234252
Disease: Mechanical pain
Mechanical pain 		0.040 Biomarker phenotype BEFREE Here, we show that deletion of the mechanically activated and rapidly adapting Piezo2 channel in a portion of the low-threshold mechanoreceptors and a majority of the IB4-positive nociceptors impairs touch but sensitizes mechanical pain in mice. 30726728 2019
CUI: C0234252
Disease: Mechanical pain
Mechanical pain 		0.040 AlteredExpression phenotype BEFREE These findings demonstrate that human mechanical pain does not require PIEZO2 and can be signaled by fast-conducting, thickly myelinated afferents. 31281886 2019
CUI: C0234252
Disease: Mechanical pain
Mechanical pain 		0.040 Biomarker phenotype BEFREE Recently, we reported that Merkel cells modulate the development of mechanical itch under the conditions of dry skin and aging, whereas two other studies demonstrated that Piezo2 channel mediates mechanical pain. 31001848 2019
CUI: C0234252
Disease: Mechanical pain
Mechanical pain 		0.040 Biomarker phenotype BEFREE However, the role of Piezo2 in acute and sensitized mechanical pain is not well defined. 30305457 2018