We conclude that Blimp-1 rather than Hobit mediates the formation of CD8<sup>+</sup> T<sub>RM</sub> cells in the lungs, potentially through control of the lineage choice between T<sub>CM</sub> and T<sub>RM</sub> cells during the differentiation of influenza-specific CD8<sup>+</sup> T cells.
In this study, we examined ASC differentiation independent of T cell help and germinal center reactions using mice with inducible or B cell-specific deletions of <i>Ezh2</i> Following stimulation with influenza virus or LPS, <i>Ezh2</i>-deficient ASC poorly proliferated and inappropriately maintained expression of inflammatory pathways, B cell-lineage transcription factors, and Blimp-1-repressed genes, leading to fewer and less functional ASC.