PRDM1, PR/SET domain 1, 639

N. diseases: 126; N. variants: 8
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 AlteredExpression disease BEFREE We also showed that interruption of Blimp-1/Aiolos regulatory pathways contributes to lenalidomide-mediated anti-MM activity. 26823144 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 AlteredExpression disease BEFREE Importantly, we found that the anti-MM activity of miR-125b-5p was mediated via direct downregulation of IRF4 and its downstream effector BLIMP-1. 25987254 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 AlteredExpression disease BEFREE The expression of ASK1 and Blimp-1 showed an inverse correlation between normal human mature B cells and bone marrow plasma cells from patients with multiple myeloma (MM). 22723553 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 Biomarker disease BEFREE Blimp-1 ASODN and Xbp-1 ASODN clearly inhibited myeloma cell differentiation and significantly partially inhibited the differentiation effects induced by 2ME2 at low concentration, whereas PAX-5 ASODN clearly induced myeloma cell differentiation and significantly enhanced 2ME2-induced differentiation effects. 18192112 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 AlteredExpression disease LHGDN The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells. 17043021 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 AlteredExpression disease BEFREE Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. 16002735 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.070 AlteredExpression disease BEFREE We hypothesize that premature Blimp-1 expression coupled to altered and deficient Pax5 expression causes some proliferating B cells to prematurely differentiate to plasma cells in MM. 12453881 2002