PRDM1, PR/SET domain 1, 639

N. diseases: 126; N. variants: 8
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE Downregulation of PRDM1 promotes cellular invasion and lung cancer metastasis. 28378641 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE Moreover, we demonstrate that Blimp1 triggers cell invasion and metastasis formation via its effects on focal adhesion and survival signaling. 28442738 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE These findings support a model in which upregulation of BLIMP1 links microenvironmental cues to a metastatic stem cell character.<b>Significance:</b> PDAC is an almost uniformly lethal cancer, largely due to its tendency for metastasis. 28790031 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 GeneticVariation phenotype BEFREE Recent GWAS study identified rs4946728 and rs1040411 noncoding SNPs located between PRDM1 and ATG1 genes on chromosome 6q21 as risk factors for secondary malignancies in patients formerly treated with radiotherapy for pediatric Hodgkin disease. 24306881 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE PRDM1 is associated with radiation-induced secondary malignancies and a small number of genes are associated with treatment-related toxicities. 25205514 2014