Disease: Secondary Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 GeneticVariation group BEFREE We report a series of 10 patients carrying pathogenic variants in the SDHD gene from five tertiary referral centers for paraganglioma (PGL) in the Netherlands, who presented with a sympathetic PGL (sPGL), pheochromocytoma (PHEO), or metastases outside the head and neck region in the absence of excessive catecholamine production. 31194241 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 Biomarker group BEFREE By contrast, the higher number of genetic abnormalities required for tumor initiation and maintenance in SDHB PPGL result in a lower penetrance of PGL, but when cells give rise to metastases they are assumed to be better adapted to sustain survival. 30106970 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 GeneticVariation group BEFREE Succinate:fumarate ratios were higher in both SDHB-mutated and metastatic tumors than in those due to SDHD/C mutations or without metastases. 25014000 2014
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 Biomarker group BEFREE Analysis of SDHD can also help to distinguish synchronous primary tumors from abdominal metastases. 15774781 2005