Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0043395
Disease: Yellow Fever
Yellow Fever
0.060 GeneticVariation disease BEFREE Structure-Function of the Yellow Fever Virus Envelope Protein: Analysis of Antibody Epitopes. 31682201 2020
CUI: C0043395
Disease: Yellow Fever
Yellow Fever
0.060 Biomarker disease BEFREE The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles internalized and processed by E-specific B cells. 28827760 2017
CUI: C0043395
Disease: Yellow Fever
Yellow Fever
0.060 AlteredExpression disease BEFREE We used wild-type YF virus sequences to generate recombinant envelope protein in an Escherichia coli expression system. 27307452 2016
CUI: C0043395
Disease: Yellow Fever
Yellow Fever
0.060 Biomarker disease BEFREE To investigate biological effects of recombination between a chimeric yellow fever (YF) 17D/Japanese encephalitis (JE) vaccine virus (ChimeriVax-JE) and a wild-type flavivirus Kunjin (KUN-cDNA), the prM-E envelope protein genes were swapped between the two viruses, resulting in new YF 17D/KUN(prM-E) and KUN/JE(prM-E) chimeras. 17693000 2007
CUI: C0043395
Disease: Yellow Fever
Yellow Fever
0.060 GeneticVariation disease BEFREE A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys. 15331733 2004
CUI: C0043395
Disease: Yellow Fever
Yellow Fever
0.060 GeneticVariation disease BEFREE Nucleotide sequence variation of the envelope protein gene identifies two distinct genotypes of yellow fever virus. 7637022 1995