|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the effect of n-3 PUFA in the early stage of atherosclerosis in FH patients by evaluating in vivo (peripheral arterial tonometry [PAT]) and in vitro (plasma asymmetric dimethylarginine and E-selectin) endothelial function.
|
31543373 |
2019 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among our most noteworthy findings are that DHL exerts an inhibitory effect against the increased expression of VCAM-1 and E-selectin induced by exposure to oxidized low-density lipoprotein (ox-LDL), which has been linked to the development and progression of atherosclerosis.
|
31632584 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ASN002 showed dose-dependent plasma exposure with low interpatient variability, significantly downregulated several serum biomarkers involved in Th1, Th2 and Th17/Th22 immunity, and decreased the atherosclerosis-associated biomarker E selectin/SELE.
|
30919407 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with the loss of H<sub>2</sub>S, human antigen R sulfhydration was attenuated in atherosclerosis and resulted in the stabilization of human antigen R-target mRNAs, for example, CD62E and cathepsin S, both of which are linked to endothelial cell activation and atherosclerosis.
|
29970364 |
2019 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs1805193, rs5361, and rs5355 single nucleotide polymorphisms in the E-selectin gene (SEL-E) are associated with subclinical atherosclerosis: The Genetics of Atherosclerotic Disease (GEA) Mexican study.
|
30501958 |
2019 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Endothelial activation with up-regulation of E-selectin adhesion molecules mediates leukocyte rolling along the vascular wall and controls inflammation in many diseases including atherosclerosis and heart failure.
|
30165141 |
2018 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present review highlights the role of various miRNAs in controlling the expression of E-selectin, ICAM-1, and VCAM-1: a type of regulation that can be harnessed for therapeutic prevention of inflammation-associated diseases such as atherosclerosis and sepsis.
|
29565737 |
2018 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The initiation of atherosclerosis involves up-regulation of molecules such as E-selectin, VCAM-1, and ICAM-1.
|
29288721 |
2018 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-1185 modulated the expression of VCAM-1 and E-selectin to promote arterial stiffening, suggesting that miR-1185 plays a crucial role in the development of atherosclerosis and may serve as a novel therapeutic target for atherosclerosis.
|
28441665 |
2017 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we further compare the role of <i>P. gingivalis</i> cells and their vesicles in expression of chemoattractant proteins including CXCL1, CXCL2, and CXCL8, and adhesive molecules such as E-selectin in human umbilical vein endothelial cells (HUVECs).Both <i>P. gingivalis</i> 33277 cells and vesicles were able to up-regulate expression of these molecules, while the vesicles acted as more potent inducers of the inflammatory response associated with the development of atherosclerosis, consequently resulting in significant monocyte adhesion to a monolayer of HUVECs.
|
27826542 |
2016 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
E-selectin is an important inflammatory cytokine involved in the pathogenesis of various diseases such as atherosclerosis and stroke.
|
24249306 |
2014 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ser 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.
|
22648254 |
2012 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effect on atherosclerosis was paralleled by a reduced expression of the vascular inflammation markers and adhesion molecules inter-cellular adhesion molecule-1 and E-selectin.
|
21411607 |
2011 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
E-selectin polymorphisms are an independent atherosclerosis and coronary artery disease (CAD) risk factor.
|
21629188 |
2011 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism of the E-selectin gene has been implicated in the pathogenesis of atherosclerosis.
|
19420919 |
2009 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A surface glycoprotein molecule, E-selectin is involved in adhesion of circulating leukocyte to the activated endothelium and plays a fundamental role in pathogenesis of atherosclerosis.
|
19942746 |
2009 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) Ser128Arg in the E-selectin gene is overrepresented in certain patient populations with atherosclerosis or restenosis.
|
16908800 |
2006 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) Ser128Arg in the E-selectin gene is overrepresented in certain patient groups with atherosclerosis or restenosis.
|
15546947 |
2005 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The aim of this study was to assess E-selectin Ser128Arg polymorphism in subjects with clinical and instrumental evidence of atherosclerosis and to analyze the correlations with clinical severity.
|
15179350 |
2004 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess E-selectin Ser128Arg polymorphism in subjects with clinical and instrumental evidence of atherosclerosis and to analyze the correlations with clinical severity.
|
15179350 |
2004 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The E-selectin gene (SELE) Arg128, 98T, and Phe554 alleles may increase the risk of atherosclerosis, but not necessarily the risk of MI.
|
14575520 |
2003 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition the range of results was so wide and the overlap of values with normal controls so great, that the use of an individual level of either VCAM, ICAM or E-selectin was not predictive of either the presence or degree of atherosclerosis in the FH subjects.
|
10699426 |
2000 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In E-selectin, exchanges from serine to arginine (position 128), from leucine to phenylalanine (position 554), and a DNA mutation from guanine to thymine (position 98) present significantly different allele frequencies in young patients with angiographically established, severe atherosclerosis, compared with an unselected population.
|
8557254 |
1996 |