Finally, we demonstrated that Malat1 binds to Bim and E-selectin both <i>in vitro</i> and <i>in vivo</i> Our study suggests that Malat1 plays critical protective roles in ischemic stroke.<b>SIGNIFICANCE STATEMENT</b> Accumulative studies have demonstrated the important regulatory roles of microRNAs in vascular and neural damage after ischemic stroke.
The aim of the present study was to evaluate the association of E-selectinS128R polymorphism with hemorrhagic stroke and also to evaluate the genotypic and allelic variation with ischemic stroke in a South Indian population from Andhra Pradesh.
Our current study demonstrates that the E-selectin SNP A561C is associated with increased risk for the development of ischemic stroke in this subset of the Han Chinese population.
Cerebral vascular endothelium assume a proadhesive phenotype after ischemic stroke that favors the recruitment of BMSCs, which use both P- and E-selectin to home into the infarct site.