|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Evidence of linkage of the inflammatory bowel disease susceptibility locus on chromosome 16 (IBD1) to ulcerative colitis.
|
9541106 |
1998 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.
|
9636179 |
1998 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Two European genome-wide screens for inflammatory bowel disease have identified two significant regions of linkage on chromosomes 16 (IBD1) and 12 (IBD2) and two regions with suggestive levels of significance (chromosomes 3p and 7q).
|
9797357 |
1998 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The present study performed in a Southern European population provides additional support for the conclusion with the IBD1 locus has a clear role in the genetic susceptibility to IBD.
|
10439963 |
1999 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Since IL-4 regulation and expression are abnormal in IBD, the IL4R gene is thus both a positional and functional candidate for IBD1.
|
10663555 |
2000 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent genome scans and replication studies have identified replicated linkage between CD and a locus on chromosome 16 (the IBD1 locus), replicated linkage between IBD (especially UC) and a locus on chromosome 12q (the IBD2 locus), and replicated linkage between IBD (especially CD) and a locus on chromosome 6p (the IBD3 locus).
|
10747815 |
2000 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In our study the IBD1 locus was found to have a major role in IBD predisposition in the Italian population.
|
11093274 |
2000 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In inflammatory bowel disease (IBD), linkage to two regions has elsewhere been reported at genomewide significance levels: the pericentromeric region on chromosome 16 (IBD1) and chromosome 12q (IBD2).
|
11309682 |
2001 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A susceptibility locus for inflammatory bowel disease (IBD) on chromosome 16 (IBD1) has been linked to Crohn's disease in genome-wide linkage studies.
|
11318544 |
2001 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Methods We sequenced the coding region of the NOD2 gene and genotyped an insertion polymorphism affecting the leucine-rich region of the protein product in 512 individuals with IBD from 309 German or British families, 369 German trios (ie, German patients with sporadic IBD and their unaffected parents), and 272 normal controls.
|
11425413 |
2001 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.
|
11752413 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.
|
11752413 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
The new information summarized here includes: the discovery of the association of the NOD2 gene with Crohn's disease; the role of bacteria and the modulating effects of probiotics; the inverse association of appendectomy and ulcerative colitis; progress in imaging based on magnetic resonance imaging and leukocyte scintigraphy; assessment of the value of anti-Saccharomyces cerevisiae antibodies in the screening of inflammatory bowel disease and differentiation between ulcerative colitis and Crohn's disease; and risk factors and management of dysplasia and cancer.
|
11778131 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
|
11875755 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
|
11875755 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease.
|
11910337 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Inflammatory bowel disease (IBD) is a polygenic disorder, as demonstrated by epidemiological evidence, genetic linkage, and the identification of the first susceptibility gene, NOD2.
|
12073072 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed inflammatory bowel disease (IBD), 197 cases of AS associated with IBD (referred to as colitic spondylarthritis; comprising 78 with CD and 119 with ulcerative colitis [UC]), and 229 ethnically matched, healthy controls.
|
12115195 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Two cohorts of consecutively identified patients referred to an inflammatory bowel disease center (n = 142 collected between 1993 and 1996; n = 59 collected between 1999 and 2001) were genotyped for 3 single nucleotide variants of NOD2-R675W, G881R, and 3020insC-and phenotyped for disease behavior, disease location, and serum immune markers.
|
12198692 |
2002 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Because CARD4/NOD1 shares many structural and functional similarities with CARD15, we tested its putative role in IBD.
|
12477763 |
2003 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
LHGDN |
Genetics of inflammatory bowel disease: scientific and clinical implications.
|
12617879 |
2003 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We investigated 198 sporadic CD patients, 46 probands with familial CD, 27 CD probands from mixed IBD families, 99 unrelated patients with ulcerative colitis (UC), and 300 control individuals for the occurrence of the CARD15 gene variants R702W, G908R, and 1007fs.
|
12631669 |
2003 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Epidemiological and genetic linkage studies have indicated a strong genetic basis for development of inflammatory bowel disease (IBD) which was recently supported by discovery of the Crohn's disease (CD) susceptibility gene termed NOD2/CARD15.
|
12634858 |
2003 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Although CARD15 3020insC appears to be etiologically important in CD, homozygous carriage does not always lead to IBD.
|
12650796 |
2003 |
|
Inflammatory Bowel Diseases
|
0.500 |
AlteredExpression
|
group |
LHGDN |
Together with the mutation-derived truncation and functional change of the NOD2 protein, this could be part of the complex pathophysiology of barrier disruption as it is observed in inflammatory bowel diseases.
|
12671897 |
2003 |