Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we report a case of familial sarcoidosis with typical thoracic sarcoidosis and carrying the NOD2 2722G > C variant.
|
29554915 |
2018 |
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we can conclude that there is no association between the CARD15 gene and the development or a special phenotype of sarcoidosis in our cohort.
|
21388357 |
2011 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CARD15 genotypes did not differ between the unselected sarcoidosis cohort and controls.
|
19679608 |
2010 |
Sarcoidosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.
|
19116920 |
2009 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that in general, CARD15 mutations may not contribute to the risk of sarcoidosis.
|
18384487 |
2008 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of a CARD15 mutation-positive patient with Blau syndrome who exhibited interstitial lung disease, a feature historically considered absent from Blau syndrome, while typical of the adult form of sarcoidosis.
|
17393391 |
2007 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of exon 4 of the CARD15 gene containing mutations associated with Blau syndrome was performed by polymerase chain reaction and sequencing of genomic DNA from 52 patients with histologically verified sarcoidosis.
|
20298285 |
2007 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of CARD15 mutations is not increased in ethnic Danish patients with sarcoidosis, and heterozygosity for such mutations apparently has no influence on the course of disease.
|
16397396 |
2007 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the G908R mutation of the CARD15/NOD2 gene, as well as the T allele and TT genotype of the CD14 promoter are associated with increased susceptibility for developing sarcoidosis.
|
16933467 |
2006 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Pediatric granulomatous arthritis: an international registry.
|
17009307 |
2006 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOD2 mutations have been shown to predispose to granulomatous diseases, including Crohn's disease, Blau syndrome, and early-onset sarcoidosis, but not to adult sarcoidosis.
|
16935475 |
2006 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
CARD15/NOD2, CD14, and toll-like receptor 4 gene polymorphisms in Greek patients with sarcoidosis.
|
16933467 |
2006 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome.
|
15459013 |
2005 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this work was to determine the frequencies of the three major NOD2/CARD 15 gene mutations (R702W, G908R and 1007fsinC) in a series of 76 subjects affected by IPF, and to compare them with those found in three groups of controls: a group with sarcoidosis (a disorder in which an involvement of the NOD2/CARD15 gene has already been investigated and rejected in different ethnic groups; 67 subjects) and two groups of healthy subjects (218 and 208 subjects, respectively), matched for gender, age, and ethnicity.
|
16315780 |
2005 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOD2 polymorphisms were found in 26 patients with sarcoidosis (13 with uveitis).
|
14597055 |
2003 |
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, CARD15 mutations, which are important in Crohn's disease and Blau syndrome, play no major role in sarcoidosis in this study population.
|
14621080 |
2003 |