|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, cesarean section appeared to interact with immune response genes, including CD25 and in particular the interferon-induced helicase 1 gene, where increased risk for type 1 diabetes was only seen in children who were delivered by cesarean section and had type 1 diabetes-susceptible IFIH1 genotypes (12-year risk, 9.1 vs. <3% for all other combinations; P < 0.0001).
|
22110093 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, a clear association has not been yet established between T1D-associated IFIH1 polymorphisms and enterovirus detection.
|
23549392 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three very recent reports provide convincing statistical evidence (P < 10(-8)), at a genome-wide level, of the association of common polymorphisms with three different common diseases: systemic lupus erythematosus (IRF5), prostate cancer and type 1 diabetes (IFIH1 region).
|
16804532 |
2006 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evidence for association with T1D was observed for the IFIH1 SNP, rs1990760 (P=7.0 x 10(-4)), with RR=0.88 (0.82-0.95) and the CTLA4 SNP rs1427676 (P=0.0005), with RR=1.14 (1.06-1.23).
|
19956106 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An application to a recently published study on Type-1 Diabetes finds rare variants in gene IFIH1 to be protective against Type-1 Diabetes.
|
21304886 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The IFIH1 rs1990760 polymorphism was genotyped in 1055 patients of Central-Eastern European ancestry with T1DM (median age at diagnosis: 8.2 [interquartile range, IQR 4.8-11.8] years).
|
28929635 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This is not the case for IFIH1, as population genetic differentiation and haplotype analyses indicated that the T1D susceptibility alleles behaved as neutral or nearly neutral polymorphisms.
|
20538742 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, association between IFIH1 Ala946Thr and type 1 diabetes was investigated in two distinct white populations, the Hungarians and Finns.
|
19841890 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, the A946T mutation of MDA5, which has been implicated in type I diabetes by previous genetic analyses, affected neither dsRNA binding nor IFN gene activation.
|
19324880 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Host genes, such as IFIH1, that influence susceptibility to T1DM are associated with antiviral activities.
|
20351698 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of PTPN22, CTLA4, and IFIH1 variants with T1D were investigated in a sample of 197 nuclear families, including 205 affected children, in the Colombian population.
|
25042601 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we showed a significant association of two rare IFIH1 variants, rs35744605 (rs35744605" genes_norm="64135">E627X) and rs35667974 (rs35667974" genes_norm="64135">I923V), with decreased risk of type 1 diabetes (T1D) in a Russian population (for the allele X627, odds ratio [OR] = 0.39, 95% confidence interval [95% CI] = 0.22-0.69, p = 0.0015; for the allele V923, OR = 0.45, 95% CI, 0.30-0.66, p = 5.4 × 10(-5)).
|
20736039 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The rs6432714, a tag-SNP that represents part of helicase domain of IF1H1 protein showed a trend of association only with T1D development (P>0.025 after Bonferroni adjustment) in log-additive model (OR=1.45, P=0.0365, power=0.99), indicating that helicase domain of IFIH1 protein could be associated with the susceptibility to T1D.
|
23246693 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.
|
24117221 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Islet autoantibody-positive children with the IFIH1 rs2111485 GG genotype had a faster progression to diabetes (31% within 5 years) than children with the type 1 diabetes protective GA or AA genotypes (11% within 5 years; P = 0.006).
|
21270278 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated (1) whether enterovirus is present at the onset of T1D in peripheral blood mononuclear cells (PBMC), plasma, throat, or stool, and (2) whether enteroviral presence is linked with HLA-DR type and/or polymorphisms in melanoma differentiation-associated gene 5 (MDA5) and 2'-5' oligoadenylate synthetase 1 (OAS1), factors of antiviral immunity.
|
20121407 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes.
|
17535987 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the association of the Thr946Ala SNP with T1D is not due to modulation of IFIH1 expression in organs involved in the disease, pointing to the IFIH1 nsSNP as the causal variant.
|
20644636 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associated with type 1 diabetes.
|
22789000 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping for type 1 diabetes susceptibility genes (HLA-DR/HLA-DQ, INS variable number of tandem repeats [VNTR] and single nucleotide polymorphisms at PTPN22, PTPN2, ERBB3, IL2, SH2B3, CTLA4, IFIH1, KIAA0350 [also known as CLEC16A], CD25, IL18RAP, IL10, COBL) was performed on the DNA samples of children born to a parent with type 1 diabetes and prospectively followed from birth for up to 22 years.
|
23539116 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |