|
Breast Carcinoma
|
0.360 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.360 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Pancreatic carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our findings support the notion that selective activation of tumor-suppressive MEKK4-MKK4-p38-p21signaling pathway by triptonide is a new approach for pancreatic cancer therapy, providing a new drug candidate for development of novel anti-cancer therapeutics.
|
31075266 |
2019 |
|
Pancreatic carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Pancreatic cancer tissues analysis showed that PTEN and MAP2K4 were all negatively correlated with miR-181a.
|
24532253 |
2014 |
|
Pancreatic carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate for the first time that common variants in BRCA2 and MAP2K4 are susceptibility to sporadic pancreatic cancer.
|
23299404 |
2013 |
|
Pancreatic carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.
|
15623633 |
2004 |
|
Pancreatic carcinoma
|
0.340 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Pancreatic carcinoma
|
0.340 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Ovarian Serous Adenocarcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that homozygous deletion or reduced expression of MKK4 may contribute to the development of ovarian serous carcinoma.
|
16627982 |
2006 |
|
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
BEFREE |
These results argue that MKK4 functions as a pro-oncogenic molecule instead of a suppressor in breast and pancreatic tumors.
|
15184866 |
2004 |
|
Pancreatic Neoplasm
|
0.310 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Pancreatic Neoplasm
|
0.310 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Ovarian Serous Adenocarcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Squamous cell carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Metastatic melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Benign tumor of pancreas
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Benign tumor of pancreas
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Neoplasm of uncertain or unknown behavior of breast
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Neoplasm of uncertain or unknown behavior of breast
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast adenocarcinoma
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast adenocarcinoma
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Sleep Deprivation
|
0.200 |
Biomarker
|
phenotype |
RGD |
Influence of sleep deprivation on expression of MKK4 and c-fos in the mandibular condylar cartilage of rats.
|
23859770 |
2013 |
|
Brain Death
|
0.200 |
Biomarker
|
phenotype |
RGD |
Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death.
|
23157661 |
2012 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.
|
9195981 |
1997 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies.
|
30537492 |
2019 |