DisGeNET - a database of gene-disease associations

MAP2K4, mitogen-activated protein kinase kinase 4, 6416

N. diseases: 100; N. variants: 4

Disease: Carcinoma, Ovarian Epithelial ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

AlteredExpression

disease

BEFREE

Loss of MKK4 expression in ovarian cancer: a potential role for the epithelial to mesenchymal transition.

20309881

2011

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

AlteredExpression

disease

BEFREE

In the current study, we investigated the mechanism relating loss of MKK4 expression to the development of ovarian cancer.

21487811

2011

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

Biomarker

disease

BEFREE

Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.

17276500

2007

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

Biomarker

disease

BEFREE

Taken together, these data support a role for MKK4 in the suppression of metastatic colonization in ovarian cancer.

12438272

2002