Candidiasis, Familial, 2
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Deep dermatophytosis and inherited CARD9 deficiency.
|
24131138 |
2013 |
Candidiasis, Familial, 2
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency.
|
23335372 |
2013 |
Candidiasis, Familial, 2
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Deep dermatophytosis and inherited CARD9 deficiency.
|
24131138 |
2013 |
Candidiasis, Familial, 2
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Deep dermatophytosis and inherited CARD9 deficiency.
|
24131138 |
2013 |
Candidiasis, Familial, 2
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
|
19864672 |
2009 |
Candidiasis, Familial, 2
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
|
19864672 |
2009 |
Candidiasis, Familial, 2
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Candidiasis, Familial, 2
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
In this review, we provide mechanistic insights into the role of the CARD9 adaptor molecule in intestinal inflammation and determine a potential CARD9-targeting therapeutic approach against IBD.
|
31696662 |
2020 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
This review summarizes recent insights into the regulation of CARD9 signaling, its pathophysiological role during IBD development via effects on the microbiota and epithelial regeneration and the pro- and antitumor immune functions of CARD9 during intestinal carcinogenesis.
|
30906296 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This yeast elicits strong inflammatory cytokine production from innate cells harboring the IBD-linked polymorphism in CARD9 and exacerbates colitis via CARD9 in mouse models of disease.
|
30850233 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Given that Lyn-deficient (<i>Lyn<sup>-/-</sup>)</i> mice are susceptible to both autoimmunity and IBD, we investigated the immunological role of CARD9 in the development of these diseases using the <i>Lyn<sup>-/-</sup></i> mouse model.
|
31594855 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Reduced production of AhR ligands is also observed in the microbiota from individuals with IBD, particularly in those with CARD9 risk alleles associated with IBD.
|
28399013 |
2017 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Taken together, small molecules targeting CARD9 illustrate a path toward improved IBD therapeutics.
|
29073062 |
2017 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Because polymorphisms in Card9 were recurrently associated with human IBD, we investigated the function of Card9 in a colitis-associated cancer (CAC) model.
|
28586167 |
2017 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Reduced production of AHR ligands is also observed in the microbiota from individuals with IBD, particularly in those with CARD9 risk alleles associated with IBD.
|
27158904 |
2016 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic association between CARD9 variants and inflammatory bowel disease was not replicated in a Chinese Han population.
|
26722558 |
2015 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Here, we used a rare CARD9 variant that confers protection against inflammatory bowel disease as an entry point to investigating CARD9 regulation.
|
26488816 |
2015 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Many more than expected by chance overlapped with genes previously implicated as playing a role in IBD susceptibility in genome-wide association scans, including CARD9, ICAM3, and IL8RB (P < 0.001).
|
22419656 |
2012 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
CTD_human |
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
|
21983784 |
2011 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Upon activation, dectin-1 signaling converges, similar to NOD2, on the adaptor molecule CARD9 which is associated with inflammatory bowel disease (IBD).
|
19915667 |
2009 |