SFTPB, surfactant protein B, 6439

N. diseases: 108; N. variants: 11
Disease: Respiratory Distress Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 Biomarker disease BEFREE A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome. 28465315 2017
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 Biomarker disease BEFREE CHF5633 is a new generation synthetic surfactant containing both SP-B and SP-C analogues developed for the treatment of respiratory distress syndrome. 27973472 2017
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE There is a possible involvement of SP-A2 and SP-B genes polymorphisms in the genetic predisposition to respiratory distress syndrome. 26061924 2015
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome. 21180884 2011
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Comparison of surfactant protein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome. 17581675 2007
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Our data provide evidence that ABCA3 mutations are associated not only with a deficiency of ABCA3 but also with an abnormal processing and routing of SP-B and SP-C, leading to severe alterations of surfactant homeostasis and respiratory distress syndrome. 16728712 2006
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Genetic variants of surfactant protein B (SP-B) have been associated with respiratory distress syndrome (RDS) in the prematurely born infant. 16549540 2006
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 Biomarker disease BEFREE Surfaxin (lucinactant), a peptide-based surfactant consisting of dipalmitoylphosphatidylcholine (DPPC) plus KL(4) (sinapultide) (a synthetic peptide modeled after human surfactant protein-B), is effective in treating respiratory distress syndrome in preterm infants. 15633204 2005
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. 12483294 2003
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Specific alleles of the SP-A and SP-B genes associate interactively with susceptibility to respiratory distress syndrome. 12667827 2003
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 Biomarker disease BEFREE Surfactant replacement therapy with bovine and porcine lung surfactant extracts, which contain only polar lipids and SP-B and SP-C, has revolutionized the clinical management of premature infants with respiratory distress syndrome. 11001826 2000
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 SusceptibilityMutation disease ORPHANET Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. 11063734 2000
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 Biomarker disease BEFREE Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B. 9475280 1998
CUI: C0852283
Disease: Respiratory Distress Syndrome
Respiratory Distress Syndrome 		0.400 GeneticVariation disease BEFREE Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome. 7832777 1995