SFTPC, surfactant protein C, 6440
N. diseases: 132; N. variants: 14
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.050 | Biomarker | disease | BEFREE | SNPs in several genes were associated with increased chronic respiratory morbidity (interleukin 10 (IL10), nitric oxide synthase 2A (NOS2A), surfactant protein C (SFTPC), matrix metalloproteinase 16 (MMP16) and vitamin D receptor (VDR)) and reduced lung function at 1 year (MMP16, NOS2A, SFTPC and VDR) in infants who had had RSV LRTIs. | 24487983 | 2014 |
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0.050 | Biomarker | disease | BEFREE | SP-C deficiency increases the severity of RSV-induced pulmonary inflammation through regulation of TLR3 signaling. | 19304906 | 2009 |
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0.050 | Biomarker | disease | BEFREE | The aim of this study was to test surfactant protein C for association with bronchial asthma and with severe respiratory syncytial virus associated diseases in infancy. | 17121584 | 2006 |
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0.050 | Biomarker | disease | BEFREE | The common allelic variants of SP-A1, SP-A2, SP-B, SP-C, and SP-D genes are associated with respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), or respiratory syncytial virus (RSV) bronchiolitis. | 17142161 | 2006 |
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0.050 | AlteredExpression | disease | BEFREE | However, the infection of cells expressing SP-C(Deltaexon4) with respiratory syncytial virus resulted in significantly enhanced cytotoxicity associated with accumulation of the mutant proprotein, pronounced activation of the unfolded protein response, and cell death. | 16449190 | 2006 |