|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma.
|
31549407 |
2020 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.
|
30794914 |
2019 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells.
|
31409760 |
2019 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Moreover, LAPTM4B activated ATG3 transcription to modulate HCC cell apoptosis and autophagy.
|
31118766 |
2019 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma.
|
27301338 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
More importantly, ATG3 was a target gene of miR-204-5p and ATG3 overexpression restored the effect of miR-204-5p on NSCLC cell progression.
|
31849486 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
The effects of ATG3 alteration on proliferation and invasion were further analyzed.
|
31849517 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Results revealed that miR-16 was significantly downregulated, and ATG3 was significantly upregulated in NSCLC patient tissue samples.
|
29138833 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Also, Western blot and RT-qPCR assays manifested that ATG3 was highly expressed in DDP resistant NSCLC tissues and cells.
|
29851226 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Inhibition of autophagy by Atg3 and Atg7 knockdown or by chloroquine treatment prevented degradation of PDE4A and activation of cAMP/PKA/CREB signalling, suppressing TGF-β1 expression, EMT and invasion in hepatocarcinoma cells.
|
30134011 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Recombinant TGF-β1 was capable of rescuing EMT and invasion that was inhibited by siRNA for Atg3 and 7 in HepG2 and BEL7402 cells under starvation.
|
23430956 |
2013 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Eventually, Western blot, plate clone formation and Transwell invasion assays proved that autophagy block could antagonize the promotive functions of ATG3 on proliferation and invasion in cancer suggesting autophagy activation accounts for the promotive role of ATG3 on proliferation and invasion in colon cancer.
|
31849517 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Molecular mechanisms underlying Atg8 lipidation remain poorly understood despite association of Atg3, the E1 Atg7, and the composite E3 Atg12-Atg5-Atg16 with pathologies including cancers, infections and neurodegeneration.
|
31399562 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Studies have indicated that ATG3 could mediate the effects of other tumor-related regulators in carcinogenesis.
|
31849517 |
2019 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In addition, Meg3 protected ATG3 mRNA from degradation following treatment with actinomycin D. Overall, our results suggest that the lncRNA Meg3 acts as a tumor suppressor in EOC by regulating ATG3 activity and inducing autophagy.
|
28423647 |
2017 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Upregulated expression of Meg3 also suppressed tumorigenesis in vivo in a xenograft mouse model through upregulating ATG3 expression.
|
28423647 |
2017 |
|
leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
According to a gene expression microarray, atg3 is downregulated in MDS patients progressing to leukemia, but less is known about the function of Atg3 in the survival and death of MSD/AML cells.
|
27391105 |
2016 |
|
Childhood Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
According to a gene expression microarray, atg3 is downregulated in MDS patients progressing to leukemia, but less is known about the function of Atg3 in the survival and death of MSD/AML cells.
|
27391105 |
2016 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
AlteredExpression
|
group |
BEFREE |
According to a gene expression microarray, atg3 is downregulated in MDS patients progressing to leukemia, but less is known about the function of Atg3 in the survival and death of MSD/AML cells.
|
27391105 |
2016 |
|
leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on the nested case-control study cohort and gene expression profile, we have picked up a subset of six genes to distinguish the leukemia group and control group stably.ATG3 is the only down regulated gene.
|
24420857 |
2014 |
|
Childhood Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on the nested case-control study cohort and gene expression profile, we have picked up a subset of six genes to distinguish the leukemia group and control group stably.ATG3 is the only down regulated gene.
|
24420857 |
2014 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
AlteredExpression
|
group |
BEFREE |
This research is to investigate the effect of ATG3 gene over expression by lentivirus on SKM-1 cell line and myelodysplastic syndrome to leukemic transformation.
|
24420857 |
2014 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Blocking autophagy using pharmacologic inhibitors (3-methyladenine, chloroquine, and bafilomycin A) or genetic inhibitors (siRNA targeting Atg3 and Atg7) enhanced cell death induced by Akt inhibitor AZD5363 in these tumor prostate cell lines.
|
23258740 |
2013 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ATG3 is upregulated in colon cancer tissues and cells demonstrated by qPCR and IHC.
|
31849517 |
2019 |
|
Endometriosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of EPHA3 inhibited the activation of the mTOR signaling pathway, down-regulated bcl-2 expression, up-regulated the expression of Atg3, LC3-II/LC3-I, Beclin1, bax and fas, and also promoted the autophagy and apoptosis of macrophages in endometriosis mice.<b>Conclusion:</b> Altogether, EPHA3 could potentially promote the autophagy and apoptosis of macrophages in endometriosis via inhibition of the mTOR signaling pathway, highlighting the potential of EPHA3 as the target to treat endometriosis.
|
31262977 |
2019 |